NESS 0327
Modify Date: 2025-08-25 19:03:05
NESS 0327 structure
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Common Name | NESS 0327 | ||
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| CAS Number | 494844-07-4 | Molecular Weight | 489.825 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C24H23Cl3N4O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
Use of NESS 0327NESS 0327 is a cannabinoid antagonist with high selectivity for the cannabinoid CB1 receptor. NESS 0327 is more than 60,000-fold selective for the CB1 receptor[1]. |
| Name | 8-chloro-1-(2,4-dichlorophenyl)-N-piperidin-1-yl-5,6-dihydro-4H-benzo[2,3]cyclohepta[2,4-b]pyrazole-3-carboxamide |
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| Synonym | More Synonyms |
| Description | NESS 0327 is a cannabinoid antagonist with high selectivity for the cannabinoid CB1 receptor. NESS 0327 is more than 60,000-fold selective for the CB1 receptor[1]. |
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| Related Catalog | |
| References |
| Density | 1.5±0.1 g/cm3 |
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| Molecular Formula | C24H23Cl3N4O |
| Molecular Weight | 489.825 |
| Exact Mass | 488.093750 |
| PSA | 50.16000 |
| LogP | 6.66 |
| Index of Refraction | 1.705 |
| InChIKey | NCXBPZJQQSNIRA-UHFFFAOYSA-N |
| SMILES | O=C(NN1CCCCC1)c1nn(-c2ccc(Cl)cc2Cl)c2c1CCCc1cc(Cl)ccc1-2 |
| Storage condition | -20℃ |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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Synthesis and characterization of NESS 0327: a novel putative antagonist of the CB1 cannabinoid receptor.
J. Pharmacol. Exp. Ther. 306 , 363-370, (2003) The compound N-piperidinyl-[8-chloro-1-(2,4-dichlorophenyl)-1,4,5,6-tetrahydrobenzo [6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide] (NESS 0327) was synthesized and evaluated for binding affinity toward ... |
| 8-chloro-1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide |
| Benzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide, 8-chloro-1-(2,4-dichlorophenyl)-1,4,5,6-tetrahydro-N-1-piperidinyl- |
| NESS 0327 |
| 8-Chloro-1-(2,4-dichlorophenyl)-N-(1-piperidinyl)-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide |
| NESS-0327 |