494844-07-4

494844-07-4 structure

Name: NESS 0327
Chemical Name: 8-chloro-1-(2,4-dichlorophenyl)-N-piperidin-1-yl-5,6-dihydro-4H-benzo[2,3]cyclohepta[2,4-b]pyrazole-3-carboxamide
CAS Number: 494844-07-4
Molecular Formula: C₂₄H₂₃Cl₃N₄O
Molecular Weight: 489.825
Catalog: Signaling Pathways GPCR/G Protein Cannabinoid Receptor
Create Date: 2016-03-22 11:04:32
Modify Date: 2025-08-25 19:03:05
NESS 0327 is a cannabinoid antagonist with high selectivity for the cannabinoid CB1 receptor. NESS 0327 is more than 60,000-fold selective for the CB1 receptor[1].

Name	8-chloro-1-(2,4-dichlorophenyl)-N-piperidin-1-yl-5,6-dihydro-4H-benzo[2,3]cyclohepta[2,4-b]pyrazole-3-carboxamide
Synonyms	8-chloro-1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide Benzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide, 8-chloro-1-(2,4-dichlorophenyl)-1,4,5,6-tetrahydro-N-1-piperidinyl- NESS 0327 8-Chloro-1-(2,4-dichlorophenyl)-N-(1-piperidinyl)-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide NESS-0327

Description	NESS 0327 is a cannabinoid antagonist with high selectivity for the cannabinoid CB1 receptor. NESS 0327 is more than 60,000-fold selective for the CB1 receptor[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor
References	[1]. Ruiu S, et al. Synthesis and characterization of NESS 0327: a novel putative antagonist of the CB1 cannabinoid receptor. J Pharmacol Exp Ther. 2003;306(1):363-370.

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