Ginsenoside Rk1
Modify Date: 2024-01-03 18:30:22
Ginsenoside Rk1 structure
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Common Name | Ginsenoside Rk1 | ||
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| CAS Number | 494753-69-4 | Molecular Weight | 766.998 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 854.5±65.0 °C at 760 mmHg | |
| Molecular Formula | C42H70O12 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 470.6±34.3 °C | |
Use of Ginsenoside Rk1Ginsenoside Rk1 is a unique component created by processing the ginseng plant (mainly Sung Ginseng, SG) at high temperatures[1].Ginsenoside Rk1 has anti-inflammatory effect, suppresses the activation of Jak2/Stat3 signaling pathway and NF-κB[2].Ginsenoside Rk1 has anti-tumor effect, antiplatelet aggregation activities, anti-insulin resistance, nephroprotective effect, antimicrobial effect, cognitive function enhancement, lipid accumulation reduction and prevents osteoporosis[1].Ginsenoside Rk1 induces cell apoptosis by triggering intracellular reactive oxygen species (ROS) generation and blocking PI3K/Akt pathway[3]. |
| Name | 3β,12β-dihydroxydammar-20(21),24-diene-3-O-β-D-glucopyranosyl(1->2)-β-D-glucopyranoside |
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| Synonym | More Synonyms |
| Description | Ginsenoside Rk1 is a unique component created by processing the ginseng plant (mainly Sung Ginseng, SG) at high temperatures[1].Ginsenoside Rk1 has anti-inflammatory effect, suppresses the activation of Jak2/Stat3 signaling pathway and NF-κB[2].Ginsenoside Rk1 has anti-tumor effect, antiplatelet aggregation activities, anti-insulin resistance, nephroprotective effect, antimicrobial effect, cognitive function enhancement, lipid accumulation reduction and prevents osteoporosis[1].Ginsenoside Rk1 induces cell apoptosis by triggering intracellular reactive oxygen species (ROS) generation and blocking PI3K/Akt pathway[3]. |
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| Related Catalog | |
| In Vitro | Ginsenoside Rk1 (0-40 μM; 6 hours) inhibits MCP-1 and TNF-α mRNA induced by lipopolysaccharide (LPS), expression of IL-1β is inhibited at 40 μM[2]. Ginsenoside Rk1 (0-40 μM; 24 hours) inhibits phosphorylation of JAK2 and STAT3 (Tyr705 and Ser727) in LPS-induced RAW264.7 cells in a dose-dependent manner[2]. Ginsenoside Rk1 (0-160 μM; 48 hours) results in cell viability significant decrease 75.52 ± 2.51% (40 μM), 52.72 ± 2.54% (80 μM), 17.41 ± 2.94% (120 μM)and 12.63 ± 3.24% (160 μM) compared with control[3]. Ginsenoside Rk1 (0-120 μM; 24 hours) increases G0/G1 phase proportion accompanied with S and G2/M phase proportion decrease in MDA-MB-231 cells[3]. Ginsenoside Rk1 (0-120 μM; 24 hours) promotes the percentage of apoptotic cells in a dose-dependent manner, exhibits to reduction of cell number with nucleus fragmentation, condensation and apoptotic body formation[3]. RT-PCR[2] Cell Line: RAW264.7 cells Concentration: 10 μM, 20 μM, 40 μM Incubation Time: 6 hours Result: Inhibited JAK2-dependent STAT3 activation in LPS-activated RAW264.7 cells. Western Blot Analysis[2] Cell Line: RAW264.7 cells Concentration: 10 μM, 20 μM, 40 μM Incubation Time: 6 hours Result: Inhibited JAK2-dependent STAT3 activation in LPS-activated RAW264.7 cells Cell Viability Assay[3] Cell Line: MDA-MB-231 cells Concentration: 0 μM, 40 μM, 80 μM, 120 μM Incubation Time: 48 hours Result: Inhibited MDA-MB-231 cells proliferation in a dose- and time-dependent manner. Cell Cycle Analysis[3] Cell Line: MDA-MB-231 cells Concentration: 0 μM, 40 μM, 80 μM, 120 μM Incubation Time: 24 hours Result: Induced G0/G1 phase arrest. Apoptosis Analysis[3] Cell Line: MDA-MB-231 cells Concentration: 0 μM, 40 μM, 80 μM, 120 μM Incubation Time: 24 hours Result: Induced apoptosis in MDA-MB-231 cells. |
| References |
[1]. Elshafay A, et al. Ginsenoside Rk1 bioactivity: a systematic review. PeerJ. 2017 Nov 17;5:e3993. |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 854.5±65.0 °C at 760 mmHg |
| Molecular Formula | C42H70O12 |
| Molecular Weight | 766.998 |
| Flash Point | 470.6±34.3 °C |
| Exact Mass | 766.486755 |
| PSA | 198.76000 |
| LogP | 6.70 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Index of Refraction | 1.589 |
| Storage condition | -20℃ |
| GINSENOSIDE RK2 |
| Ginsenoside Rk1 |
| β-D-Glucopyranoside, (3β,12β)-12-hydroxydammara-20,24-dien-3-yl 2-O-β-D-glucopyranosyl- |
| (3β,12β)-12-Hydroxydammara-20,24-dien-3-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside |
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Ginsenoside Rk1
- Price: ￥1458.0/10mg
- Purity: 98.0%
- Stocking Period: 2 Day
- Contact: Liu jia
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