propyphenazone

Modify Date: 2025-08-21 18:51:18

propyphenazone structure	Common Name	propyphenazone
	CAS Number	479-92-5	Molecular Weight	230.305
	Density	1.1±0.1 g/cm3	Boiling Point	319.0±25.0 °C at 760 mmHg
	Molecular Formula	C₁₄H₁₈N₂O	Melting Point	102-105°C
	MSDS	Chinese USA	Flash Point	123.8±15.5 °C
	Symbol	GHS07	Signal Word	Warning

Use of propyphenazone

Propyphenazone is a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors.Target：COX-2Propyphenazone is structurally related to aminophenazone it has been associated with severe blood dyscrasias. Propyphenazone is introduced for the treatment of rheumatic disorders.

Name	propyphenazone
Synonym	More Synonyms

Description	Propyphenazone is a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors.Target：COX-2Propyphenazone is structurally related to aminophenazone it has been associated with severe blood dyscrasias. Propyphenazone is introduced for the treatment of rheumatic disorders.
Related Catalog	Research Areas >> Inflammation/Immunology
Target	COX
References	[1]. Burdan F, et al. Formation of the knee joint after prenatal propyphenazone (isopropylantipyrine) administration. Cells Tissues Organs. 2002;171(2-3):145-51.

Density	1.1±0.1 g/cm3
Boiling Point	319.0±25.0 °C at 760 mmHg
Melting Point	102-105°C
Molecular Formula	C₁₄H₁₈N₂O
Molecular Weight	230.305
Flash Point	123.8±15.5 °C
Exact Mass	230.141907
PSA	26.93000
LogP	1.74
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.556
InChIKey	PXWLVJLKJGVOKE-UHFFFAOYSA-N
SMILES	Cc1c(C(C)C)c(=O)n(-c2ccccc2)n1C
Storage condition	Refrigerator
Stability	Stable. Incompatible with strong oxidizing agents.

propyphenazone MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CD2800000

CHEMICAL NAME :: Antipyrine, 4-isopropyl-

CAS REGISTRY NUMBER :: 479-92-5

BEILSTEIN REFERENCE NO. :: 0204533

LAST UPDATED :: 199701

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C14-H18-N2-O

MOLECULAR WEIGHT :: 230.34

WISWESSER LINE NOTATION :: T5NNVJ A1 BR& DY1&1 E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 860 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 97,601,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 960 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,401,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 295 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 122,434,1959

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 61,205,1937

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 61,205,1937

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1050 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SMWOAS Schweizerische Medizinische Wochenschrift. (Schwabe & Co., Steintorst 13, 4010 Basel, Switzerland) V.50- 1920- Volume(issue)/page/year: 84,351,1954

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
Hazard Codes	Xn
Risk Phrases	R36/37/38
Safety Phrases	S26-S36/37/39
RIDADR	NONH for all modes of transport
RTECS	CD2800000
HS Code	2933110000

N-desmethylprop...

CAS#:50993-68-5

Dimethyl sulfate

CAS#:77-78-1

propyphenazone

CAS#:479-92-5

Literature: Yakugaku Zasshi, , vol. 57, p. 953,958; dtsch. Ref. S. 269 Chem.Abstr., , p. 2533 DE558473 , ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 19, p. 1186

Precursor 2
CAS#:50993-68-5 N-desmethylprop... CAS#:77-78-1 Dimethyl sulfate
DownStream 8
CAS#:881-05-0 5-methyl-2-phen... CAS#:38604-70-5 N-methyl-N-phen... CAS#:22123-18-8 4-isopropyl-5-m... CAS#:298-12-4 Glyoxylic acid
CAS#:1672-63-5 4-hydroxyantipyrine CAS#:50871-97-1 5-hydroxy-1,5-d... CAS#:89080-91-1 2-acetyl-3-meth... CAS#:105798-28-5 2-Hydroxy-2-iso...

HS Code	2933199090
Summary	2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Development of a multicommuted flow-through optosensor for the determination of a ternary pharmaceutical mixture.

J. Pharm. Biomed. Anal. 43(2) , 515-21, (2007)

The combination of multicommutation and flow-through multioptosensing is presented in this work as a powerful strategy for the routine analysis of active principles in pharmaceuticals. By coupling met...

Green chromatography separation of analytes of greatly differing properties using a polyethylene glycol stationary phase and a low-toxic water-based mobile phase.

Anal. Bioanal. Chem 405(18) , 6105-15, (2013)

A simple, rapid, and environmentally friendly HPLC method was developed and validated for the separation of four compounds (4-aminophenol, caffeine, paracetamol, and propyphenazone) with different che...

VUV photon-induced ionization/dissociation of antipyrine and propyphenazone: mass spectrometric and theoretical insights.

J. Mass Spectrom. 45(7) , 734-9, (2010)

Two analgesic and anti-inflammatory drugs, antipyrine and propyphenazone, were investigated with infrared laser desorption/tunable synchrotron vacuum ultraviolet (VUV) photoionization mass spectrometr...

ANTIBIOTICTPJ-B

causyth

2,3-Dimethyl-1-phenyl-4-isopropylpyrazolone

budirol

PROPYLPHENAZONE

MFCD00053368

arantil P

3H-Pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl-

Isopropylphenazone

Isopropyrine

Propyphenazon

Isopropylantipyrine

cibalgina

4-Isopropyl-2,3-dimethyl-1-phenyl-5-pyrazolone

1,2-Dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl-3H-pyrazol-3-one

isopropylantipyrin

EINECS 207-539-2

1,5-dimethyl-4-(1-methylethyl)-2-phenyl-1,2-dihydro-3H-pyrazol-3-one

propyphenazone

Isopyrine

Isopropylantipyrinum

Larodon

Eufibron

4-Isopropyl-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one

4-Isopropylantipyrine

Isopropchin

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China
Product Name: propyphenazone
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China
Product Name: propyphenazone
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Propyphenazone
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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propyphenazone

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