2-Methylthioadenosine diphosphate trisodium

Modify Date: 2024-01-10 20:34:14

2-Methylthioadenosine diphosphate trisodium structure	Common Name	2-Methylthioadenosine diphosphate trisodium
	CAS Number	475193-31-8	Molecular Weight	539.23800
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₁H₁₄N₅Na₃O₁₀P₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 2-Methylthioadenosine diphosphate trisodium

2-Methylthioadenosine diphosphate trisodium is a potent purinergic P2Y receptors agonist, with EC50s of 19, 6.2, and 5 nM for human P2Y13, mouse P2Y13 and human P2Y12, respectively. 2-Methylthioadenosine diphosphate trisodium has pEC50s of 8.29 and 5.75 for human P2Y1 and rat P2Y6, respectively. 2-Methylthioadenosine diphosphate trisodium induces platelet aggregation and shape change, and inhibits cyclic AMP accumulation in platelets exposed to prostaglandin E1[1][2][3].

Name	2-(Methylthio)adenosine 5′-diphosphate trisodium salt hydrate
Synonym	More Synonyms

Description	2-Methylthioadenosine diphosphate trisodium is a potent purinergic P2Y receptors agonist, with EC50s of 19, 6.2, and 5 nM for human P2Y13, mouse P2Y13 and human P2Y12, respectively. 2-Methylthioadenosine diphosphate trisodium has pEC50s of 8.29 and 5.75 for human P2Y1 and rat P2Y6, respectively. 2-Methylthioadenosine diphosphate trisodium induces platelet aggregation and shape change, and inhibits cyclic AMP accumulation in platelets exposed to prostaglandin E1[1][2][3].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> P2Y Receptor Research Areas >> Neurological Disease
In Vitro	2-Methylthioadenosine diphosphate trisodium (2-Methylthio-ADP trisodium) is a powerful aggregating agent for human platelets. 2-Methylthioadenosine diphosphate trisodium is also a powerful inhibitor of the accumulation of cyclic AMP in intact platelets exposed to PGE1 and a phosphodiesterase inhibitor[1].
References	[1]. Zhang FL, et al. P2Y(13): identification and characterization of a novel Galphai-coupled ADP receptor from human and mouse. J Pharmacol Exp Ther. 2002;301(2):705-713. [2]. Sak K, et al. A retrospective of recombinant P2Y receptor subtypes and their pharmacology. Arch Biochem Biophys. 2002;397(1):131-136. [3]. Macfarlane DE, et al. 2-Methylthioadenosine[beta-32P]diphosphate. An agonist and radioligand for the receptor that inhibits the accumulation of cyclic AMP in intact blood platelets. J Clin Invest. 1983;71(3):420-428.

Molecular Formula	C₁₁H₁₄N₅Na₃O₁₀P₂S
Molecular Weight	539.23800
Exact Mass	538.96300
PSA	286.01000
LogP	0.87170

MSDS(Chinese)

Trisodium 2-(methylsulfanyl)-5'-O-[(phosphonatooxy)phosphinato]ad enosine

DC Chemicals Limited
China
Product Name: 2-MeS-ADP
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Get all suppliers and price by the below link:

2-Methylthioadenosine diphosphate trisodium suppliers

Price: ￥5200/5 mg

Reference only. check more 2-Methylthioadenosine diphosphate trisodium price

2-Methylthioadenosine diphosphate trisodium

Use of 2-Methylthioadenosine diphosphate trisodium

Names

Biological Activity

Chemical & Physical Properties

MSDS

Synonyms