2-Methylthioadenosine diphosphate trisodium
Names
[ CAS No. ]:
475193-31-8
[ Name ]:
2-Methylthioadenosine diphosphate trisodium
[Synonym ]:
Trisodium 2-(methylsulfanyl)-5'-O-[(phosphonatooxy)phosphinato]ad enosine
Biological Activity
[Description]:
2-Methylthioadenosine diphosphate trisodium is a potent purinergic P2Y receptors agonist, with EC50s of 19, 6.2, and 5 nM for human P2Y13, mouse P2Y13 and human P2Y12, respectively. 2-Methylthioadenosine diphosphate trisodium has pEC50s of 8.29 and 5.75 for human P2Y1 and rat P2Y6, respectively. 2-Methylthioadenosine diphosphate trisodium induces platelet aggregation and shape change, and inhibits cyclic AMP accumulation in platelets exposed to prostaglandin E1[1][2][3].
[Related Catalog]:
[In Vitro]
2-Methylthioadenosine diphosphate trisodium (2-Methylthio-ADP trisodium) is a powerful aggregating agent for human platelets. 2-Methylthioadenosine diphosphate trisodium is also a powerful inhibitor of the accumulation of cyclic AMP in intact platelets exposed to PGE1 and a phosphodiesterase inhibitor[1].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C11H14N5Na3O10P2S
[ Molecular Weight ]:
539.23800
[ Exact Mass ]:
538.96300
[ PSA ]:
286.01000
[ LogP ]:
0.87170