Akt-l-1

Modify Date: 2024-01-31 18:50:41

Akt-l-1 Structure
Akt-l-1 structure
Common Name Akt-l-1
CAS Number 473382-39-7 Molecular Weight 378.514
Density 1.2±0.1 g/cm3 Boiling Point N/A
Molecular Formula C22H30N6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Akt-l-1


AKT-I-1 is a selective inhibitor of Akt1, with an IC50 of 4.6 µM[1].

 Names

Name N-(7-cyclobutyl-3-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-N',N',2,2-tetramethylpropane-1,3-diamine
Synonym More Synonyms

 Akt-l-1 Biological Activity

Description AKT-I-1 is a selective inhibitor of Akt1, with an IC50 of 4.6 µM[1].
Related Catalog
Target

Akt1:4.6 μM (IC50)

Akt2:>250 μM (IC50)

Akt3:>250 μM (IC50)

References

[1]. Barnett SF, et al. Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors. Biochem J. 2005 Jan 15;385(Pt 2):399-408.  

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Molecular Formula C22H30N6
Molecular Weight 378.514
Exact Mass 378.253204
PSA 61.58000
LogP 4.01
Index of Refraction 1.642

 Precursor & DownStream

Precursor  2

DownStream  0

 Synonyms

1,3-Propanediamine, N-(7-cyclobutyl-3-phenyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)-N,N,2,2-tetramethyl-
Akt-l-1
N'-(7-Cyclobutyl-3-phenyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-N,N,2,2-tetramethyl-1,3-propanediamine