Akt-l-1

Names

[ Name ]:
Akt-l-1

[Synonym ]:
1,3-Propanediamine, N-(7-cyclobutyl-3-phenyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)-N,N,2,2-tetramethyl-
Akt-l-1
N'-(7-Cyclobutyl-3-phenyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-N,N,2,2-tetramethyl-1,3-propanediamine

Biological Activity

[Description]:

AKT-I-1 is a selective inhibitor of Akt1, with an IC50 of 4.6 µM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PI3K/Akt/mTOR >> Akt

[Target]

Akt1:4.6 μM (IC50)

Akt2:>250 μM (IC50)

Akt3:>250 μM (IC50)

[References]

[1]. Barnett SF, et al. Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors. Biochem J. 2005 Jan 15;385(Pt 2):399-408.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Molecular Formula ]:
C₂₂H₃₀N₆

[ Molecular Weight ]:
378.514

[ Exact Mass ]:
378.253204

[ PSA ]:
61.58000

[ LogP ]:
4.01

[ Index of Refraction ]:
1.642

Precursor & DownStream

Precursor

DownStream

Related Compounds

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