2′-O-(2-Methoxyethyl)guanosine

Modify Date: 2025-08-21 19:49:20

2′-O-(2-Methoxyethyl)guanosine Structure
2′-O-(2-Methoxyethyl)guanosine structure
 Common Name 2′-O-(2-Methoxyethyl)guanosine
CAS Number 473278-54-5 Molecular Weight 341.32000
Density 1.811g/cm3 Boiling Point N/A
Molecular Formula C13H19N5O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 2′-O-(2-Methoxyethyl)guanosine


2′-O-(2-Methoxyethyl)guanosine (2'-O-MOE-rG), a 2′-O-methoxyethyl-modified nucleoside, can be produced by enzymatic conversion (adenosine deaminase) from 2′-O-(2-methoxyethyl)-2,6-diaminopurine riboside. 2′-O-(2-Methoxyethyl)guanosine neither effectively phosphorylated by cytosolic nucleoside kinases, nor are they incorporated into cellular DNA or RNA[1][2].

 Names

Name 2'-O-(2-Methoxyethyl)-guanosine
Synonym More Synonyms

 2′-O-(2-Methoxyethyl)guanosine Biological Activity

Description 2′-O-(2-Methoxyethyl)guanosine (2'-O-MOE-rG), a 2′-O-methoxyethyl-modified nucleoside, can be produced by enzymatic conversion (adenosine deaminase) from 2′-O-(2-methoxyethyl)-2,6-diaminopurine riboside. 2′-O-(2-Methoxyethyl)guanosine neither effectively phosphorylated by cytosolic nucleoside kinases, nor are they incorporated into cellular DNA or RNA[1][2].
Related Catalog
References

[1]. McPherson AK, et, al. An Improved Process for the Manufacture of 5′-O-(4,4′-Dimethoxytrityl)-N2-isobutyryl-2′-O-(2-methoxyethyl)guanosine. Org. Process Res. Dev. 2020, 24, 11, 2583-2590.

[2]. Saleh AF, et, al. 2'-O-(2-Methoxyethyl) Nucleosides Are Not Phosphorylated or Incorporated Into the Genome of Human Lymphoblastoid TK6 Cells. Toxicol Sci. 2018 May 1;163(1):70-78.

 Chemical & Physical Properties

Density 1.811g/cm3
Molecular Formula C13H19N5O6
Molecular Weight 341.32000
Exact Mass 341.13400
PSA 157.74000
Index of Refraction 1.745

 Safety Information

Hazard Codes Xi
HS Code 2909199090

 Customs

HS Code 2909199090
Summary 2909199090. other acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

 Synonyms

2-amino-9-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)oxolan-2-yl]-3H-purin-6-one
2'-O-(2-Methoxyethyl)guanosine
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