3a-(3,4-dimethoxyphenyl)-1-methyl-octahydro-1H-indol-6(2H)-one

Modify Date: 2025-08-25 08:45:37

3a-(3,4-dimethoxyphenyl)-1-methyl-octahydro-1H-indol-6(2H)-one structure	Common Name	3a-(3,4-dimethoxyphenyl)-1-methyl-octahydro-1H-indol-6(2H)-one
	CAS Number	468-53-1	Molecular Weight	289.36900
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇H₂₃NO₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 3a-(3,4-dimethoxyphenyl)-1-methyl-octahydro-1H-indol-6(2H)-one

Mesembrine ((+)-Mesembrine) a main alkaloid that features an aryloctahydroindole skeleton. Mesembrine is a 5-HT transporter inhibitor with a Ki of 1.4 nM. Mesembrine also inhibits phosphodiesterase 4B (PDE4B) with an IC50 of 7.8 μM[1][2].

Name	3a-(3,4-dimethoxyphenyl)-1-methyl-octahydro-1H-indol-6(2H)-one
Synonym	More Synonyms

Description	Mesembrine ((+)-Mesembrine) a main alkaloid that features an aryloctahydroindole skeleton. Mesembrine is a 5-HT transporter inhibitor with a Ki of 1.4 nM. Mesembrine also inhibits phosphodiesterase 4B (PDE4B) with an IC50 of 7.8 μM[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	PDE4B:7.8 μM (IC50) serotonin:1.4 nM (Ki)
In Vitro	Mesembrine can bind to cloned human cannabinoid CB1 receptors in vitro[1].
References	[1]. John L Krstenansky. Mesembrine alkaloids: Review of their occurrence, chemistry, and pharmacology. J Ethnopharmacol. 2017 Jan 4;195:10-19. [2]. Golo M J Meyer, et al. GC-MS, LC-MS(n), LC-high resolution-MS(n), and NMR studies on the metabolism and toxicological detection of mesembrine and mesembrenone, the main alkaloids of the legal high "Kanna" isolated from Sceletium tortuosum. Anal Bioanal Chem. 2015 Jan;407(3):761-78.

Molecular Formula	C₁₇H₂₃NO₃
Molecular Weight	289.36900
Exact Mass	289.16800
PSA	38.77000
LogP	2.33660
Vapour Pressure	3.09E-07mmHg at 25°C

Hazard Codes	Xi

mesembrine

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 3a-(3,4-dimethoxyphenyl)-1-methyl-octahydro-1H-indol-6(2H)-one
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: (+)-mesembrine
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Mesembrine
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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Use of 3a-(3,4-dimethoxyphenyl)-1-methyl-octahydro-1H-indol-6(2H)-one

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