Neritaloside

Modify Date: 2025-09-01 12:05:46

Use of Neritaloside

Neritaloside could be isolated from nerium oleander. Neritaloside has central nervous system (CNS) depressant effect[1][2.

Name	Neritaloside
Synonym	More Synonyms

Description	Neritaloside could be isolated from nerium oleander. Neritaloside has central nervous system (CNS) depressant effect[1][2.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	Neritaloside (human tumor cell lines) has antitumor activity with mean IC50 value and mean IC70 value of 0.120 μM and 0.252 μM, respectively[1].
In Vivo	Neritaloside (25 mg/kg; i.p.; for 6 hours; mice of NMRI strain) exhibits central nervous system depressant activity in mice at a dose of 25 mg/kg[2. Animal Model: Mice of NMRI strain (18-22 g) [2 Dosage: 25 mg/kg Administration: Intraperitoneal injection; for 6 hours Result: Showed sedation in mice at 25 mg/kg dose.
References	[1]. Rashan LJ, et, al. Characterization of the anticancer properties of monoglycosidic cardenolides isolated from Nerium oleander and Streptocaulon tomentosum. J Ethnopharmacol. 2011 Apr 12;134(3):781-8. [2]. Begum S, et, al. Bio-active cardenolides from the leaves of Nerium oleander. Phytochemistry. 1999 Feb;50(3):435-8.

Density	1.3±0.1 g/cm3
Boiling Point	729.4±60.0 °C at 760 mmHg
Molecular Formula	C₃₂H₄₈O₁₀
Molecular Weight	592.718
Flash Point	229.4±26.4 °C
Exact Mass	592.324768
PSA	140.98000
LogP	3.00
Vapour Pressure	0.0±5.4 mmHg at 25°C
Index of Refraction	1.578
InChIKey	UZQOZJNEDXAJEZ-JWMMVCOUSA-N
SMILES	COC1C(O)C(C)OC(OC2CCC3(C)C(CCC4C3CCC3(C)C(C5=CC(=O)OC5)C(OC(C)=O)CC43O)C2)C1O

Hazard Codes	Xi

Card-20(22)-enolide, 16-(acetyloxy)-3-[(6-deoxy-3-O-methyl-β-D-galactopyranosyl)oxy]-14-hydroxy-, (3β,5β,16β)-

(3β,5β,16β)-16-Acetoxy-3-[(6-deoxy-3-O-methyl-β-D-galactopyranosyl)oxy]-14-hydroxycard-20(22)-enolide

Get all suppliers and price by the below link: