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465-13-4

465-13-4 structure
465-13-4 structure
  • Name: Neritaloside
  • Chemical Name: Neritaloside
  • CAS Number: 465-13-4
  • Molecular Formula: C32H48O10
  • Molecular Weight: 592.718
  • Catalog: Natural product Steroidal compound
  • Create Date: 2017-01-17 23:24:20
  • Modify Date: 2024-01-19 12:41:00
  • Neritaloside could be isolated from nerium oleander. Neritaloside has central nervous system (CNS) depressant effect[1][2.
Name Neritaloside
Synonyms Card-20(22)-enolide, 16-(acetyloxy)-3-[(6-deoxy-3-O-methyl-β-D-galactopyranosyl)oxy]-14-hydroxy-, (3β,5β,16β)-
(3β,5β,16β)-16-Acetoxy-3-[(6-deoxy-3-O-methyl-β-D-galactopyranosyl)oxy]-14-hydroxycard-20(22)-enolide
Description Neritaloside could be isolated from nerium oleander. Neritaloside has central nervous system (CNS) depressant effect[1][2.
Related Catalog
In Vitro Neritaloside (human tumor cell lines) has antitumor activity with mean IC50 value and mean IC70 value of 0.120 μM and 0.252 μM, respectively[1].
In Vivo Neritaloside (25 mg/kg; i.p.; for 6 hours; mice of NMRI strain) exhibits central nervous system depressant activity in mice at a dose of 25 mg/kg[2. Animal Model: Mice of NMRI strain (18-22 g) [2 Dosage: 25 mg/kg Administration: Intraperitoneal injection; for 6 hours Result: Showed sedation in mice at 25 mg/kg dose.
References

[1]. Rashan LJ, et, al. Characterization of the anticancer properties of monoglycosidic cardenolides isolated from Nerium oleander and Streptocaulon tomentosum. J Ethnopharmacol. 2011 Apr 12;134(3):781-8.

[2]. Begum S, et, al. Bio-active cardenolides from the leaves of Nerium oleander. Phytochemistry. 1999 Feb;50(3):435-8.

Density 1.3±0.1 g/cm3
Boiling Point 729.4±60.0 °C at 760 mmHg
Molecular Formula C32H48O10
Molecular Weight 592.718
Flash Point 229.4±26.4 °C
Exact Mass 592.324768
PSA 140.98000
LogP 3.00
Vapour Pressure 0.0±5.4 mmHg at 25°C
Index of Refraction 1.578
Hazard Codes Xi
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