SPP-DM1

Modify Date: 2025-09-12 20:15:37

SPP-DM1 Structure
SPP-DM1 structure
Common Name SPP-DM1
CAS Number 452072-20-7 Molecular Weight 967.541
Density 1.4±0.1 g/cm3 Boiling Point N/A
Molecular Formula C44H59ClN4O14S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SPP-DM1


SPP-DM1 is a drug-linker conjugate for ADC with potent antitumor activity by using DM1 (a potent microtubule-disrupting agent), linked via the ADC linker SPP[1].

 Names

Name DM1-SPP

 SPP-DM1 Biological Activity

Description SPP-DM1 is a drug-linker conjugate for ADC with potent antitumor activity by using DM1 (a potent microtubule-disrupting agent), linked via the ADC linker SPP[1].
Related Catalog
Target

Maytansinoids

References

[1]. Manu Lopus et al. Maytansine and Cellular Metabolites of Antibody-Maytansinoid Conjugates Strongly Suppress Microtubule Dynamics by Binding to Microtubules.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Molecular Formula C44H59ClN4O14S2
Molecular Weight 967.541
Exact Mass 966.315796
LogP 4.78
Index of Refraction 1.617
InChIKey ZMOVORWFEGTIJA-AVPRGJHPSA-N
SMILES COc1cc2cc(c1Cl)N(C)C(=O)CC(OC(=O)C(C)N(C)C(=O)CCSSC(C)CCC(=O)ON1C(=O)CCC1=O)C1(C)OC1C(C)C1CC(O)(NC(=O)O1)C(OC)C=CC=C(C)C2
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