FXa-IN-1

Modify Date: 2025-11-11 20:23:57

FXa-IN-1 structure	Common Name	FXa-IN-1
	CAS Number	441328-10-5	Molecular Weight	487.42500
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₁₈F₅N₅O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of FXa-IN-1

FXa-IN-1 is a FXa inhibitor (IC50: 3 nM, Ki: 0.7 nM) with respectable oral bioavailability and half-life in vivo. FXa-IN-1 can be used for thromboembolic disorders[1].

Name	N-{4-[(E)-(Dimethylhydrazono)methyl]-2-fluorophenyl}-1-(3-fluoro- 2-naphthyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Description	FXa-IN-1 is a FXa inhibitor (IC50: 3 nM, Ki: 0.7 nM) with respectable oral bioavailability and half-life in vivo. FXa-IN-1 can be used for thromboembolic disorders[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Factor Xa
Target	FXa[1]
In Vivo	FXa-IN-1 (compound 22, rats) exhibits good oral bioavailability (F%: 46.9) and half-life (t1/2: 8.8 h, i.v.)[1].
References	[1]. Zhaozhong J Jia, et al. 1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor Xa inhibitors. Part 3: Design, synthesis and SAR of orally bioavailable benzamidine-P4 inhibitors. Bioorg Med Chem Lett. 2004 Mar 8;14(5):1229-34.

Molecular Formula	C₂₄H₁₈F₅N₅O
Molecular Weight	487.42500
Exact Mass	487.14300
PSA	66.01000
LogP	5.85430

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