441328-10-5

441328-10-5 structure

Name: FXa-IN-1
Chemical Name: N-{4-[(E)-(Dimethylhydrazono)methyl]-2-fluorophenyl}-1-(3-fluoro- 2-naphthyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide
CAS Number: 441328-10-5
Molecular Formula: C₂₄H₁₈F₅N₅O
Molecular Weight: 487.42500
Catalog: Signaling Pathways Metabolic Enzyme/Protease Factor Xa
Create Date: 2016-02-11 17:27:34
Modify Date: 2024-04-09 12:20:27
FXa-IN-1 is a FXa inhibitor (IC50: 3 nM, Ki: 0.7 nM) with respectable oral bioavailability and half-life in vivo. FXa-IN-1 can be used for thromboembolic disorders[1].

Name	N-{4-[(E)-(Dimethylhydrazono)methyl]-2-fluorophenyl}-1-(3-fluoro- 2-naphthyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Description	FXa-IN-1 is a FXa inhibitor (IC50: 3 nM, Ki: 0.7 nM) with respectable oral bioavailability and half-life in vivo. FXa-IN-1 can be used for thromboembolic disorders[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Factor Xa
Target	FXa[1]
In Vivo	FXa-IN-1 (compound 22, rats) exhibits good oral bioavailability (F%: 46.9) and half-life (t1/2: 8.8 h, i.v.)[1].
References	[1]. Zhaozhong J Jia, et al. 1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor Xa inhibitors. Part 3: Design, synthesis and SAR of orally bioavailable benzamidine-P4 inhibitors. Bioorg Med Chem Lett. 2004 Mar 8;14(5):1229-34.