FXa-IN-1

Names

[ Name ]:
FXa-IN-1

Biological Activity

[Description]:

FXa-IN-1 is a FXa inhibitor (IC50: 3 nM, Ki: 0.7 nM) with respectable oral bioavailability and half-life in vivo. FXa-IN-1 can be used for thromboembolic disorders[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> Factor Xa

[Target]

FXa[1]

[In Vivo]

FXa-IN-1 (compound 22, rats) exhibits good oral bioavailability (F%: 46.9) and half-life (t1/2: 8.8 h, i.v.)[1].

[References]

[1]. Zhaozhong J Jia, et al. 1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor Xa inhibitors. Part 3: Design, synthesis and SAR of orally bioavailable benzamidine-P4 inhibitors. Bioorg Med Chem Lett. 2004 Mar 8;14(5):1229-34.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₁₈F₅N₅O

[ Molecular Weight ]:
487.42500

[ Exact Mass ]:
487.14300

[ PSA ]:
66.01000

[ LogP ]:
5.85430

Related Compounds

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