Ethisterone

Modify Date: 2024-01-02 13:25:21

Ethisterone Structure
Ethisterone structure
 Common Name Ethisterone
CAS Number 434-03-7 Molecular Weight 312.446
Density 1.1±0.1 g/cm3 Boiling Point 446.4±45.0 °C at 760 mmHg
Molecular Formula C21H28O2 Melting Point 266-273ºC
MSDS Chinese USA Flash Point 190.2±21.3 °C
Symbol GHS08
GHS08		 Signal Word Danger

 Names

Name ethisterone
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 446.4±45.0 °C at 760 mmHg
Melting Point 266-273ºC
Molecular Formula C21H28O2
Molecular Weight 312.446
Flash Point 190.2±21.3 °C
Exact Mass 312.208923
PSA 37.30000
LogP 3.86
Vapour Pressure 0.0±2.5 mmHg at 25°C
Index of Refraction 1.572
Storage condition 2~8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU5570250
CHEMICAL NAME :
17-alpha-Pregn-4-en-20-yn-3-one, 17-hydroxy-
CAS REGISTRY NUMBER :
434-03-7
BEILSTEIN REFERENCE NO. :
1889895
LAST UPDATED :
199612
DATA ITEMS CITED :
17
MOLECULAR FORMULA :
C21-H28-O2
MOLECULAR WEIGHT :
312.49
WISWESSER LINE NOTATION :
L E5 B666 OV MUTJ A1 E1 FQ F1UU1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
168 mg/kg
SEX/DURATION :
female 3 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 76,626,1958
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
386 mg/kg
SEX/DURATION :
female 6-28 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 84,962,1962
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
21 mg/kg
SEX/DURATION :
female 11-15 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
JCEMAZ Journal of Clinical Endocrinology and Metabolism. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.12- 1952- Volume(issue)/page/year: 19,1369,1959
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
81900 ug/kg
SEX/DURATION :
female 16-28 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
JCEMAZ Journal of Clinical Endocrinology and Metabolism. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.12- 1952- Volume(issue)/page/year: 19,1369,1959
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
79800 ug/kg
SEX/DURATION :
female 8-26 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
JCEMAZ Journal of Clinical Endocrinology and Metabolism. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.12- 1952- Volume(issue)/page/year: 18,559,1958
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
56 mg/kg
SEX/DURATION :
female 15-39 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
JCEMAZ Journal of Clinical Endocrinology and Metabolism. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.12- 1952- Volume(issue)/page/year: 18,559,1958
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
DOSE :
56 mg/kg
SEX/DURATION :
female 15-39 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
JCEMAZ Journal of Clinical Endocrinology and Metabolism. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.12- 1952- Volume(issue)/page/year: 18,559,1958
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
DOSE :
92 mg/kg
SEX/DURATION :
female 7-39 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 11,148,1960
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
200 mg/kg
SEX/DURATION :
female 17-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
ECJPAE Endocrinologia Japonica. (Japan Pub. Trading Co., Ltd., POB 5030, Tokyo International, Tokyo, Japan) V.1- 1954- Volume(issue)/page/year: 24,77,1977
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
10 mg/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles)
REFERENCE :
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 5,282,1954
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
288 mg/kg
SEX/DURATION :
male 9 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 100,540,1959
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
10 mg/kg
SEX/DURATION :
male 10 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 100,540,1959
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
280 mg/kg
SEX/DURATION :
female 14 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 5,57,1972
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
140 mg/kg
SEX/DURATION :
female 14 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 5,57,1972
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
5 mg/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
ACEDAB Acta Endocrinologica, Supplementum (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) No.1- 1948- Volume(issue)/page/year: 28,18,1956 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80411 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 2770 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80411 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 4354 (estimated) No. of Female Employees: 729 (estimated)

 Safety Information

Symbol GHS08
GHS08
Signal Word Danger
Hazard Statements H360
Precautionary Statements P201-P308 + P313
Personal Protective Equipment Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes Xn:Harmful
Risk Phrases R40;R48
Safety Phrases S22-S24/25
RIDADR UN 2811
WGK Germany 3
RTECS TU5570250
Hazard Class 6.1
HS Code 2942000000

 Synthetic Route

21-bromo-17α-hydroxy-4-pregnene-3,20-dione structure

21-bromo-17α-hy...

CAS#:20380-17-0

~%

Ethisterone Structure

Ethisterone

CAS#:434-03-7

reichstein's substance s 21-acetate structure

reichstein's su...

CAS#:640-87-9
Literature: The Upjohn Company Patent: US4041055 A1, 1977 ;
Androstenedione structure

Androstenedione

CAS#:63-05-8
Acetylene structure

Acetylene

CAS#:74-86-2

~95%

Ethisterone Structure

Ethisterone

CAS#:434-03-7
Literature: Kataoka, Hideaki; Watanabe, Kiyoshi; Miyazaki, Ken-ichi; Tahara, Shin-ichiro; Ogu, Ken-ichi; et al. Chemistry Letters, 1990 , # 9 p. 1705 - 1708
Pregn-5-en-20-yne-3,17-diol,(3b,17a)- structure

Pregn-5-en-20-y...

CAS#:3604-60-2

~%

Ethisterone Structure

Ethisterone

CAS#:434-03-7
Literature: Inhoffen et al. Chemische Berichte, 1938 , vol. 71, p. 1024,1030 Full Text Show Details Schering Corp. Patent: US2323911 , 1937 ;
3-ethoxy-17α-ethynylandrosta-3,5-dien-17β-ol-3-one structure

3-ethoxy-17α-et...

CAS#:24594-68-1

~%

Ethisterone Structure

Ethisterone

CAS#:434-03-7
Literature: Inhoffen; Koester Chemische Berichte, 1939 , vol. 72, p. 595,596
Androstenedione structure

Androstenedione

CAS#:63-05-8

~%

Ethisterone Structure

Ethisterone

CAS#:434-03-7
Literature: Schering A.G. Patent: DE1016707 , 1957 ;

 Customs

HS Code 2942000000

 Articles29

More Articles
Evolutionary history and functional characterization of androgen receptor genes in jawed vertebrates.

Endocrinology 150 , 5415-27, (2009)

Vertebrates show diverse sexual characters in sexually attractive and reproductive organs, which are regulated by steroid hormones, particularly androgens. However, the evolutionary history of androge...
An updated steroid benchmark set and its application in the discovery of novel nanomolar ligands of sex hormone-binding globulin.

J. Med. Chem. 51 , 2047-56, (2008)

A benchmark data set of steroids with known affinity for sex hormone-binding globulin (SHBG) has been widely used to validate popular molecular field-based QSAR techniques. We have expanded the data s...
Extended use of transdermal norelgestromin/ethinyl estradiol: a randomized trial.

Obstet. Gynecol. 105(6) , 1389-96, (2005)

To compare bleeding profiles and satisfaction among women using a norelgestromin/ethinyl estradiol (E2) transdermal contraceptive patch in an extended regimen to those among women using a traditional ...

 Synonyms

Progestoral
Produxan
17α-Ethynyl-17β-hydroxyandrost-4-en-3-one
17α-Ethinyltestosterone
Lutidon Oral
Anhydrohydroxyprogesterone
Lucorteum Oral
Lutocylol
17-α-Ethynyltestosterone
17-β-Hydroxy-17-α-ethynyl-4-androsten-3-one
17a-Ethynyl-17b-hydroxy-4-androsten-3-one
Prone
Trosinone
Progestolets
Nugestoral
Lutocyclin
EINECS 207-093-9
17β-Hydroxy-4,17α-pregnen-20-yn-3-one
Prodroxan
Nalutoral
Gestoral
17a-Ethynyl-4-androsten-17b-ol-3-one
Pranone
Ethinyltestosterone
Pregneninolone
4,17α-Pregnen-17β-ol-20-yn-3-one
MFCD00002476
Ethinone
Androst-4-en-3-one, 17α-ethynyl-17-hydroxy-
Primolut C
Prolutol
17α-Pregn-4-en-20-yn-3-one, 17-hydroxy-
Proluton C
Prodoxan
17α-Ethynyltestosterone
Ora-Lutin
17a-Ethynyltestosterone
17-Ethynyl-17β-hydroxyandrost-4-en-3-one
(17α)-17-Hydroxypregn-4-en-20-yn-3-one
17a-Ethinyltestosterone
Aethisteron
Testosterone, 17-ethynyl-
Colutoid
Progestab
Pregn-4-en-20-yn-3-one, 17-hydroxy-, (17α)-
Pregnin
Progestin P
Syngestrotabs
Anhydroxyprogesterone
Ethisterone
Top Suppliers:I want be here
  • DC Chemicals Limited
  • China
  • Product Name: Aethisteron
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

Get all suppliers and price by the below link:

Ethisterone suppliers

Price: $72/100mg

Reference only. check more Ethisterone price

Related Compounds: More...
2-(hydroxymethyl)ethisterone
2787-03-3
2-Hydroxymethylene Ethisterone
2787-02-2
Chemsrc provides Ethisterone(CAS#:434-03-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Ethisterone are included as well.>> amp version: Ethisterone

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved