Tricyclazole

Modify Date: 2025-08-23 19:11:42

Tricyclazole structure	Common Name	Tricyclazole
	CAS Number	41814-78-2	Molecular Weight	189.237
	Density	1.5±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₉H₇N₃S	Melting Point	187-188°C
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS07	Signal Word	Warning

Use of Tricyclazole

Tricyclazole is a pentaketide-derived melanin biosynthesis inhibitor and a unique fungicide for control of Pyricularia oryzae on rice[1][2].

Name	tricyclazole
Synonym	More Synonyms

Description	Tricyclazole is a pentaketide-derived melanin biosynthesis inhibitor and a unique fungicide for control of Pyricularia oryzae on rice[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	Pentaketide-derived melanin biosynthesis[1]
References	[1]. Peterson L.G. Tricyclazole for Control of Pyricularia Oryzae on Rice: the Relationship of the Mode of Action and Disease Occurrence and Development. Pest Management in Rice. Springer, Dordrecht. [2]. G.Lazarovits, et al. Tricyclazole induces melanin shunt products and inhibits altersolanol a accumulation by Alternaria solani. Pesticide Biochemistry and Physiology

Density	1.5±0.1 g/cm3
Melting Point	187-188°C
Molecular Formula	C₉H₇N₃S
Molecular Weight	189.237
Exact Mass	189.036072
PSA	58.43000
LogP	2.28
Index of Refraction	1.806

Tricyclazole MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XZ5475000

CHEMICAL NAME :: s-Triazolo(3,4-b)benzothiazole, 5-methyl-

CAS REGISTRY NUMBER :: 41814-78-2

LAST UPDATED :: 199710

DATA ITEMS CITED :: 15

MOLECULAR FORMULA :: C9-H7-N3-S

MOLECULAR WEIGHT :: 189.25

WISWESSER LINE NOTATION :: T B556 BN DNN GSJ L1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 245 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 320 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: >100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - duck

DOSE/DURATION :: >100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1540 mg/kg/13W-C

TOXIC EFFECTS :: Cardiac - changes in heart weight Liver - changes in liver weight Related to Chronic Data - changes in prostate weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10920 mg/kg/13W-C

TOXIC EFFECTS :: Liver - changes in liver weight Related to Chronic Data - death Related to Chronic Data - changes in ovarian weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 14497 mg/kg/95W-C

TOXIC EFFECTS :: Liver - fatty liver degeneration Liver - changes in liver weight Blood - normocytic anemia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 16425 mg/kg/1Y-C

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 12500 ug/L

REFERENCE :: NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 14,407,1989

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn:Harmful
Risk Phrases	R22
RIDADR	2588
RTECS	XZ5475000
Packaging Group	II
Hazard Class	6.1(a)
HS Code	2934999032

Formic Acid

CAS#:64-18-6

4-Methyl-2-benz...

CAS#:20174-68-9

~60%

Tricyclazole

CAS#:41814-78-2

Literature: Deshmukh, Manisha V. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1998 , vol. 37, # 9 p. 921 - 924

5-methyl-3-merc...

CAS#:147423-88-9

~65%

Tricyclazole

CAS#:41814-78-2

Literature: Deshmukh, Manisha V. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1998 , vol. 37, # 9 p. 921 - 924

4-Methylbenzo[d...

CAS#:1477-42-5

Tricyclazole

CAS#:41814-78-2

Literature: Deshmukh, Manisha V. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1998 , vol. 37, # 9 p. 921 - 924

4-Methyl-2-benz...

CAS#:20174-68-9

Tricyclazole

CAS#:41814-78-2

Literature: Deshmukh, Manisha V. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1998 , vol. 37, # 9 p. 921 - 924

Precursor 4
CAS#:64-18-6 Formic Acid CAS#:20174-68-9 4-Methyl-2-benz... CAS#:147423-88-9 5-methyl-3-merc... CAS#:1477-42-5 4-Methylbenzo[d...
DownStream 0

HS Code	2934200090
Summary	2934200090. other compounds containing in the structure a benzothiazole ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Melanin synthesis by Sclerotinia sclerotiorum.

Mycologia 101(3) , 296-304, (2009)

We confirmed that the melanin produced by Sclerotinia sclerotiorum is a dihydroxynaphthalene (DHN). The specific DHN melanogenesis inhibitor test that uses tricyclazole at low levels (typically 2-5 pp...

Physicochemical characterization and antioxidant activity of melanin from a novel strain of Aspergillus bridgeri ICTF-201.

Lett. Appl. Microbiol. 53(3) , 350-8, (2011)

The aim of the study is to isolate and characterize a melanin pigment from a new strain of Aspergillus bridgeri isolated from rhizosphere soil of Eucalyptus tree and to investigate its antioxidant act...

1,8-dihydroxynaphthalene (DHN)-melanin biosynthesis inhibitors increase erythritol production in Torula corallina, and DHN-melanin inhibits erythrose reductase.

Appl. Environ. Microbiol. 69(6) , 3427-34, (2003)

The yeast Torula corallina is a strong erythritol producer that is used in the industrial production of erythritol. However, melanin accumulation during culture represents a serious problem for the pu...

Tricyclazol

5-methyl-1,2,4-triazolo[3,4-b]benzothiazole

BIM

MFCD00072466

El 291

BLAS-T

Tricyclazole

BEAM

5-methyl-s-triazolo<3,4-b>benzothiazole

5-methyl[1,2,4]triazolo[3,4-b][1,3]benzothiazole

Blascide

5-methyl-1,2,4-triazolo[3,4-b][1,3]benzothiazole

SAZOLE

elanco291

EINECS 255-559-5

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China
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China
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Tricyclazole

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