Hirsutenone
Modify Date: 2025-08-20 18:01:01
Hirsutenone structure
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Common Name | Hirsutenone | ||
|---|---|---|---|---|
| CAS Number | 41137-87-5 | Molecular Weight | 328.359 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 622.0±55.0 °C at 760 mmHg | |
| Molecular Formula | C19H20O5 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 344.0±28.0 °C | |
| Symbol |
GHS09 |
Signal Word | Warning | |
Use of HirsutenoneHirsutenone is an active botanical diarylheptanoid present in Alnus species and exhibits many biological activities, including anti-inflammatory, anti-tumor promoting and anti-atopic dermatitis effects. Hirsutenone attenuates adipogenesis by binding directly to PI3K and ERK1 in a non-ATP competitive manner. Hirsutenone can be used for the study of obesity[1]. |
| Name | (4E)-1,7-Bis(3,4-dihydroxyphenyl)-4-hepten-3-one |
|---|---|
| Synonym | More Synonyms |
| Description | Hirsutenone is an active botanical diarylheptanoid present in Alnus species and exhibits many biological activities, including anti-inflammatory, anti-tumor promoting and anti-atopic dermatitis effects. Hirsutenone attenuates adipogenesis by binding directly to PI3K and ERK1 in a non-ATP competitive manner. Hirsutenone can be used for the study of obesity[1]. |
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| Related Catalog | |
| In Vitro | Hirsutenone (0-100 μM; 48 hours) inhibits adipogenesis in 3T3-L1 preadipocytes and exhibits non-toxicity at 20-100 μM[1]. Hirsutenone (0-100 μM; 48 hours) attenuates MDI-induced lipid accumulation in 3T3-L1 preadipocytes in a dose-dependent manner. In particular, HST at 40 and 80 μM significantly reduces MDI-induced adipogenesis in 3T3-L1 preadipocytes[1]. Hirsutenone (0-100 μM; 48 hours) reduces the protein expression levels of PPARg, C/EBPa, and FAS in a dose-dependent manner in 3T3-L1 preadipocytes[1]. Hirsutenone (80 μM; 20-24 hours) suppresses the cell cycle entry to S and G2/M phases occurrs at 20 hours when compares with at 20 hours. At 24 h, more cells are arrested in G1 phase (53% of total cells) when compares with the MDI-induced group which contains the majority of cells (56% of total cells) in G2/M phase[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 622.0±55.0 °C at 760 mmHg |
| Molecular Formula | C19H20O5 |
| Molecular Weight | 328.359 |
| Flash Point | 344.0±28.0 °C |
| Exact Mass | 328.131073 |
| PSA | 97.99000 |
| LogP | 2.16 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.649 |
| Storage condition | ?20°C |
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Hirsutenone CAS#:41137-87-5 |
| Literature: Venkateswarlu; Ramachandra; Rambabu; Subbaraju Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2001 , vol. 40, # 6 p. 495 - 497 |
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Hirsutenone CAS#:41137-87-5 |
| Literature: Venkateswarlu; Ramachandra; Rambabu; Subbaraju Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2001 , vol. 40, # 6 p. 495 - 497 |
|
~%
Hirsutenone CAS#:41137-87-5 |
| Literature: Venkateswarlu; Ramachandra; Rambabu; Subbaraju Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2001 , vol. 40, # 6 p. 495 - 497 |
|
~%
Hirsutenone CAS#:41137-87-5 |
| Literature: Park, Daae; Kim, Hyoung Ja; Jung, Seo Yun; Yook, Chang-Soo; Jin, Changbae; Lee, Yong Sup Chemical and Pharmaceutical Bulletin, 2010 , vol. 58, # 2 p. 238 - 241 |
| Precursor 4 | |
|---|---|
| DownStream 0 | |
| HS Code | 2914501900 |
|---|---|
| Summary | 2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |
| chikusetsusaponinivc |
| Panaxoside |
| hirsutanone |
| Ginsenoside Re std. |
| gingerenone-A |
| 4-Hepten-3-one, 1,7-bis(3,4-dihydroxyphenyl)-, (4E)- |
| gingenoside Re |
| ginsenoside-Re standard |
| ginsenoside-Re |
| (4E)-1,7-Bis(3,4-dihydroxyphenyl)hept-4-en-3-one |
| GINSENOSIDE GINSENOSIDE-RE |
| (4E)-1,7-Bis(3,4-dihydroxyphenyl)-4-hepten-3-one |
| 1,7-Bis-(3,4-dihydroxy-phenyl)-hept-4-en-3-one |
| ginsenosideb2 |
| Hirsutenone |