AMA-37
Modify Date: 2025-09-25 17:20:32
AMA-37 structure
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Common Name | AMA-37 | ||
|---|---|---|---|---|
| CAS Number | 404009-46-7 | Molecular Weight | 283.32200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H17NO3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AMA-37AMA-37, an Arylmorpholine analog, is ATP-competitive DNA-PK inhibitor, with IC50 values of 0.27 μM (DNA-PK), 32 μM (p110α), 3.7 μM (p110β), and 22 μM (p110γ), respectively[1][2]. |
| Name | (2-hydroxy-4-morpholin-4-ylphenyl)-phenylmethanone |
|---|---|
| Synonym | More Synonyms |
| Description | AMA-37, an Arylmorpholine analog, is ATP-competitive DNA-PK inhibitor, with IC50 values of 0.27 μM (DNA-PK), 32 μM (p110α), 3.7 μM (p110β), and 22 μM (p110γ), respectively[1][2]. |
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| Related Catalog | |
| Target |
IC50: 0.27 μM (DNA-PK)[1]. |
| In Vitro | AMA-37 inhbits PI3K poorly[2]. AMA-37 (20 μM) reduces the ability of UCN-01, isogranulatimide, and debromohymenialdesine, but not caffeine, to overcome G2 arrest (ρ < 0.05)[3]. Inhibition of DNA-PK with AMA37 leads to radiosensitization[3]. |
| References |
| Molecular Formula | C17H17NO3 |
|---|---|
| Molecular Weight | 283.32200 |
| Exact Mass | 283.12100 |
| PSA | 49.77000 |
| LogP | 2.52480 |
| Storage condition | -20℃ |
| AMA37 |
| ArylMorpholine Analog 37 |
| 1-(2-Hydroxy-4-morpholin-4-yl-phenyl)-phenyl-methanone |
| DNA-PK Inhibitor V |