HEMADO

Modify Date: 2025-08-20 21:20:21

HEMADO structure	Common Name	HEMADO
	CAS Number	403842-38-6	Molecular Weight	361.39600
	Density	1.46g/cm3	Boiling Point	696.8ºC at 760 mmHg
	Molecular Formula	C₁₇H₂₃N₅O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	375.2ºC

Use of HEMADO

HEMADO is a potent and selective adenosine A3 receptor agonist with a Ki of 1.1 nM at the human A3 subtype[1].

Name	HEMADO,2-(1-Hexynyl)-N-methyladenosine
Synonym	More Synonyms

Description	HEMADO is a potent and selective adenosine A3 receptor agonist with a Ki of 1.1 nM at the human A3 subtype[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor
Target	Ki: 1.1 nM (human A3 subtype)[1]
In Vitro	HEMADO (compound 8a) has Kis of 327 nM and 1230 nM for A1 and A2A and a EC50 of 100 μM for A2B receptors[2].
References	[1]. Klotz KN, et al. [3H]HEMADO— a novel tritiated agonist selective for the human adenosine A3 receptor. Eur J Pharmacol. 2007 Feb 5;556(1-3):14-8. Epub 2006 Oct 27. [2]. Volpini R, et al. N(6)-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting point for searching A(2B) ligands. J Med Chem. 2002 Jul 18;45(15):3271-9.

Density	1.46g/cm3
Boiling Point	696.8ºC at 760 mmHg
Molecular Formula	C₁₇H₂₃N₅O₄
Molecular Weight	361.39600
Flash Point	375.2ºC
Exact Mass	361.17500
PSA	125.55000
LogP	0.09420
Index of Refraction	1.677

Hazard Codes	Xn
Risk Phrases	R22
Safety Phrases	36

2-(1-Hexynyl)-N6-methyladenosine

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