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HEMADO

Names

[ CAS No. ]:
403842-38-6

[ Name ]:
HEMADO

[Synonym ]:
2-(1-Hexynyl)-N6-methyladenosine

Biological Activity

[Description]:

HEMADO is a potent and selective adenosine A3 receptor agonist with a Ki of 1.1 nM at the human A3 subtype[1].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Inflammation/Immunology
Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor

[Target]

Ki: 1.1 nM (human A3 subtype)[1]


[In Vitro]

HEMADO (compound 8a) has Kis of 327 nM and 1230 nM for A1 and A2A and a EC50 of 100 μM for A2B receptors[2].

[References]

[1]. Klotz KN, et al. [3H]HEMADO— a novel tritiated agonist selective for the human adenosine A3 receptor. Eur J Pharmacol. 2007 Feb 5;556(1-3):14-8. Epub 2006 Oct 27.

[2]. Volpini R, et al. N(6)-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting point for searching A(2B) ligands. J Med Chem. 2002 Jul 18;45(15):3271-9.

Chemical & Physical Properties

[ Density]:
1.46g/cm3

[ Boiling Point ]:
696.8ºC at 760 mmHg

[ Molecular Formula ]:
C17H23N5O4

[ Molecular Weight ]:
361.39600

[ Flash Point ]:
375.2ºC

[ Exact Mass ]:
361.17500

[ PSA ]:
125.55000

[ LogP ]:
0.09420

[ Index of Refraction ]:
1.677

Safety Information

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
36

Related Compounds