403842-38-6

403842-38-6 structure

Name: HEMADO
Chemical Name: HEMADO,2-(1-Hexynyl)-N-methyladenosine
CAS Number: 403842-38-6
Molecular Formula: C₁₇H₂₃N₅O₄
Molecular Weight: 361.39600
Catalog: Signaling Pathways GPCR/G Protein Adenosine Receptor
Create Date: 2017-03-08 23:02:08
Modify Date: 2024-01-03 12:20:56
HEMADO is a potent and selective adenosine A3 receptor agonist with a Ki of 1.1 nM at the human A3 subtype[1].

Name	HEMADO,2-(1-Hexynyl)-N-methyladenosine
Synonyms	2-(1-Hexynyl)-N6-methyladenosine

Description	HEMADO is a potent and selective adenosine A3 receptor agonist with a Ki of 1.1 nM at the human A3 subtype[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor
Target	Ki: 1.1 nM (human A3 subtype)[1]
In Vitro	HEMADO (compound 8a) has Kis of 327 nM and 1230 nM for A1 and A2A and a EC50 of 100 μM for A2B receptors[2].
References	[1]. Klotz KN, et al. [3H]HEMADO— a novel tritiated agonist selective for the human adenosine A3 receptor. Eur J Pharmacol. 2007 Feb 5;556(1-3):14-8. Epub 2006 Oct 27. [2]. Volpini R, et al. N(6)-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting point for searching A(2B) ligands. J Med Chem. 2002 Jul 18;45(15):3271-9.