fingolimod-P

Modify Date: 2025-08-21 12:01:03

fingolimod-P Structure
fingolimod-P structure
 Common Name fingolimod-P
CAS Number 402615-91-2 Molecular Weight 387.451
Density 1.2±0.1 g/cm3 Boiling Point 584.2±60.0 °C at 760 mmHg
Molecular Formula C19H34NO5P Melting Point 122-124ºC
MSDS N/A Flash Point 307.1±32.9 °C

 Use of fingolimod-P


Fingolimod phosphate (FTY720 phosphate) is an orally active sphingosine 1-phosphate (S1P) receptor agonist. Fingolimod phosphate can promote the neuroprotective effects of microglia. Fingolimod phosphate can be used for the research of multiple sclerosis and neurologic diseases[1].

 Names

Name 2-Amino-2-(hydroxymethyl)-4-(4-octylphenyl)butyl dihydrogen phosp hate
Synonym More Synonyms

 fingolimod-P Biological Activity

Description Fingolimod phosphate (FTY720 phosphate) is an orally active sphingosine 1-phosphate (S1P) receptor agonist. Fingolimod phosphate can promote the neuroprotective effects of microglia. Fingolimod phosphate can be used for the research of multiple sclerosis and neurologic diseases[1].
Related Catalog
In Vitro Fingolimod phosphate 可防止淋巴细胞移出淋巴器官并抑制自身反应性淋巴细胞浸润中枢神经系统[1]。 Fingolimod phosphate（0、1、10、100 nM）结合 S1P1 受体，下调激活的小胶质细胞产生促炎细胞因子，如肿瘤坏死因子-a、白介素-1β 和白介素-6[1]. Fingolimod phosphate（0、1、10、100 nM）也上调小胶质细胞产生脑源性神经营养因子和胶质细胞源性神经营养因子[1]。
References

[1]. Hiromi Noda, et al. Fingolimod phosphate promotes the neuroprotective effects of microglia. J Neuroimmunol. 2013 Mar 15;256(1-2):13-8.  

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 584.2±60.0 °C at 760 mmHg
Melting Point 122-124ºC
Molecular Formula C19H34NO5P
Molecular Weight 387.451
Flash Point 307.1±32.9 °C
Exact Mass 387.217468
PSA 122.82000
LogP 4.27
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.541
Storage condition 2-8℃

 Synthetic Route

phosphoric acid mono-{(R/S)-4-[2-(4-octyl-phenyl)-ethyl]-2-oxo-oxazolidin-4-ylmethyl}ester structure

phosphoric acid...

CAS#:863225-34-7

~%

fingolimod-P Structure

fingolimod-P

CAS#:402615-91-2

Literature: Albert, Rainer; Hinterding, Klaus; Brinkmann, Volker; Guerini, Danilo; Mueller-Hartwieg, Constanze; Knecht, Helmut; Simeon, Corinne; Streiff, Markus; Wagner, Trixie; Weizenbach, Karl; Zecri, Frederic; Zollinger, Markus; Cooke, Nigel; Francotte, Eric Journal of Medicinal Chemistry, 2005 , vol. 48, # 16 p. 5373 - 5377
(R/S)-4-hydroxymethyl-4-[2-(4-octylphenyl)ethyl]oxazolidin-2-one structure

(R/S)-4-hydroxy...

CAS#:847672-61-1

~%

fingolimod-P Structure

fingolimod-P

CAS#:402615-91-2

Literature: Albert, Rainer; Hinterding, Klaus; Brinkmann, Volker; Guerini, Danilo; Mueller-Hartwieg, Constanze; Knecht, Helmut; Simeon, Corinne; Streiff, Markus; Wagner, Trixie; Weizenbach, Karl; Zecri, Frederic; Zollinger, Markus; Cooke, Nigel; Francotte, Eric Journal of Medicinal Chemistry, 2005 , vol. 48, # 16 p. 5373 - 5377
(R/S)-4-[2-(4-octylphenyl)ethyl]-4-(3-oxo-1,5-dihydro-3λ5-benzo[e][1,3,2]dioxaphosphepin-3-yloxymethyl)oxazolidin-2-one structure

(R/S)-4-[2-(4-o...

CAS#:847672-62-2

~%

fingolimod-P Structure

fingolimod-P

CAS#:402615-91-2

Literature: Albert, Rainer; Hinterding, Klaus; Brinkmann, Volker; Guerini, Danilo; Mueller-Hartwieg, Constanze; Knecht, Helmut; Simeon, Corinne; Streiff, Markus; Wagner, Trixie; Weizenbach, Karl; Zecri, Frederic; Zollinger, Markus; Cooke, Nigel; Francotte, Eric Journal of Medicinal Chemistry, 2005 , vol. 48, # 16 p. 5373 - 5377
Fingolimod structure

Fingolimod

CAS#:162359-55-9

~%

fingolimod-P Structure

fingolimod-P

CAS#:402615-91-2

Literature: Albert, Rainer; Hinterding, Klaus; Brinkmann, Volker; Guerini, Danilo; Mueller-Hartwieg, Constanze; Knecht, Helmut; Simeon, Corinne; Streiff, Markus; Wagner, Trixie; Weizenbach, Karl; Zecri, Frederic; Zollinger, Markus; Cooke, Nigel; Francotte, Eric Journal of Medicinal Chemistry, 2005 , vol. 48, # 16 p. 5373 - 5377

 Synonyms

1,3,4,5,6-pentahydroxyl-2-hexanone
rac FTY720 Phosphate
phosphoric acid mono-[(R/S)-2-amino-2-hydroxymethyl-4-(4-octyl-phenyl)-butyl] ester
Frutabs
fingolimod-P
2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol mono(dihydrogenphosphate) ester
1,3-Propanediol, 2-amino-2-[2-(4-octylphenyl)ethyl]-, mono(dihydrogen phosphate) (ester)
fingolimod phosphate
levugen
FTY720-phosphate
laevosan
keto D-fructose
Fruit sugar
laevoral
2-Amino-2-(hydroxymethyl)-4-(4-octylphenyl)butyl dihydrogen phosphate
Fructosteril
2-ammonio-2-(hydroxymethyl)-4-(4-octylphenyl)butyl hydrogen phosphate
(D)-fructose
fructose powder
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