DC Chemicals Limited
China
Product Name: (S)-FTY720P
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Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

402616-26-6

402616-26-6 structure

402616-26-6 structure

Name: (S) FTY720 Phosphate
Chemical Name: (S) FTY720 Phosphate
CAS Number: 402616-26-6
Molecular Formula: C₁₉H₃₄NO₅P
Molecular Weight: 387.451
Catalog: Signaling Pathways GPCR/G Protein LPL Receptor
Create Date: 2018-08-01 21:56:45
Modify Date: 2024-01-03 17:56:04
FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury.

Name	(S) FTY720 Phosphate
Synonyms	1,3-Propanediol, 2-amino-2-[2-(4-octylphenyl)ethyl]-, mono(dihydrogen phosphate) (ester), (2S)- (S)-2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol mono(dihydrogenphosphate) ester (2S)-2-Amino-2-(hydroxymethyl)-4-(4-octylphenyl)butyl dihydrogen phosphate FTY720 (S)-Phosphate fingolimod-P 1,3-Propanediol, 2-amino-2-[2-(4-octylphenyl)ethyl]-, mono(dihydrogen phosphate) (ester) (S)-FTY720-P 2-Amino-2-(hydroxymethyl)-4-(4-octylphenyl)butyl dihydrogen phosphate 2-(S)-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol Mono(dihydrogen phosphate) Ester (S)-FTY720 2-ammonio-2-(hydroxymethyl)-4-(4-octylphenyl)butyl hydrogen phosphate (S)-FTY720-phosphate [14C]-(S)-FTY720P

Description	FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> LPL Receptor Research Areas >> Inflammation/Immunology
Target	S1PR1[1]
In Vitro	FTY720 (S)-Phosphate is an agonist of S1PR1. FTY720 (S)-Phosphate (Tys, 1 µM) maintains S1PR1 protein expression, enhances the human pulmonary artery endothelial cells barrier via S1PR1, but shows no effect on inducing ubiquitination of S1PR1. FTY720 (S)-Phosphate (0.01-50 µM) also reduces β-arrestin recruitment to S1PR1[1].
In Vivo	FTY720 (S)-Phosphate (0.5 mg/kg, i.p.) preserves S1PR1 expression in mouse lungs, is protective in bleomycin-induced acute lung injury (ALI) and attenuates lung tissue leukocyte infiltration in bleomycin-injured mice[1].
Animal Admin	Mice[1]Male C57BL/6 (20-25 g) mice 8-10 weeks old receive a single intratracheal dose of bleomycin at 0.6 U/kg (or sterile saline) on Day 0 followed immediately by intraperitoneal injection of FTY720 (S)-Phosphate (0.5 mg/kg), FTY720 (0.5 mg/kg), or saline. Additional doses of FTY720 (S)-Phosphate or FTY720 are injected on Days 3 and 6. Bronchoalveolar lavage (BAL) fluid and lungs are then collected on Day 7. BAL fluid is used to detect BAL protein levels, WBC count, and WBC differential count. Lungs are perfused with saline to remove blood for Western blot, tissue albumin, and histopathology evaluation. Peripheral blood is obtained on Day 7 for examination of total cell counts and lymphocytes. Experiments are repeated 3 times. 6-10 mice are used per experimental group[1].
References	[1]. Wang L, et al. FTY720 (s)-phosphonate preserves sphingosine 1-phosphate receptor 1 expression and exhibits superior barrier protection to FTY720 in acute lung injury. Crit Care Med. 2014 Mar;42(3):e189-99. [2]. Lingling Jia, et al. Clostridium butyricum CGMCC0313.1 Protects against Autoimmune Diabetes by Modulating Intestinal Immune Homeostasis and Inducing Pancreatic Regulatory T Cells. Front Immunol. 2017 Oct 19;8:1345.

Density	1.2±0.1 g/cm3
Boiling Point	584.2±60.0 °C at 760 mmHg
Melting Point	184-186ºC
Molecular Formula	C₁₉H₃₄NO₅P
Molecular Weight	387.451
Flash Point	307.1±32.9 °C
Exact Mass	387.217468
PSA	122.82000
LogP	4.27
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.541

RIDADR	NONH for all modes of transport

Precursor 9
847672-61-1 847672-62-2 162359-55-9 876391-67-2
876391-68-3 876391-69-4 13423-48-8 183129-84-2
249289-10-9
DownStream 0