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fingolimod-P

Names

[ CAS No. ]:
402615-91-2

[ Name ]:
fingolimod-P

[Synonym ]:
1,3,4,5,6-pentahydroxyl-2-hexanone
rac FTY720 Phosphate
phosphoric acid mono-[(R/S)-2-amino-2-hydroxymethyl-4-(4-octyl-phenyl)-butyl] ester
Frutabs
fingolimod-P
2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol mono(dihydrogenphosphate) ester
1,3-Propanediol, 2-amino-2-[2-(4-octylphenyl)ethyl]-, mono(dihydrogen phosphate) (ester)
fingolimod phosphate
levugen
FTY720-phosphate
laevosan
keto D-fructose
Fruit sugar
laevoral
2-Amino-2-(hydroxymethyl)-4-(4-octylphenyl)butyl dihydrogen phosphate
Fructosteril
2-ammonio-2-(hydroxymethyl)-4-(4-octylphenyl)butyl hydrogen phosphate
(D)-fructose
fructose powder

Biological Activity

[Description]:

Fingolimod phosphate (FTY720 phosphate) is an orally active sphingosine 1-phosphate (S1P) receptor agonist. Fingolimod phosphate can promote the neuroprotective effects of microglia. Fingolimod phosphate can be used for the research of multiple sclerosis and neurologic diseases[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> GPCR/G Protein >> LPL Receptor
Research Areas >> Inflammation/Immunology
Research Areas >> Neurological Disease

[In Vitro]

Fingolimod phosphate 可防止淋巴细胞移出淋巴器官并抑制自身反应性淋巴细胞浸润中枢神经系统[1]。 Fingolimod phosphate（0、1、10、100 nM）结合 S1P1 受体，下调激活的小胶质细胞产生促炎细胞因子，如肿瘤坏死因子-a、白介素-1β 和白介素-6[1]. Fingolimod phosphate（0、1、10、100 nM）也上调小胶质细胞产生脑源性神经营养因子和胶质细胞源性神经营养因子[1]。

[References]

[1]. Hiromi Noda, et al. Fingolimod phosphate promotes the neuroprotective effects of microglia. J Neuroimmunol. 2013 Mar 15;256(1-2):13-8.  

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
584.2±60.0 °C at 760 mmHg

[ Melting Point ]:
122-124ºC

[ Molecular Formula ]:
C19H34NO5P

[ Molecular Weight ]:
387.451

[ Flash Point ]:
307.1±32.9 °C

[ Exact Mass ]:
387.217468

[ PSA ]:
122.82000

[ LogP ]:
4.27

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.541

[ Storage condition ]:
2-8℃

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds