IW-927
Modify Date: 2024-04-05 12:02:32
IW-927 structure
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Common Name | IW-927 | ||
|---|---|---|---|---|
| CAS Number | 389142-48-7 | Molecular Weight | 441.564 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H23N3O3S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of IW-927A potent TNFα/TNFRc1 interaction antagonist with IC50 of 50 nM, with no affinity for the related cytokine receptors TNFRc2 or CD40, and no cytotoxicity (>100 uM); also blocks TNF-stimulated phosphorylation of Ikappa-B in Ramos cells (IC50=600 nM) |
| Name | IW-927 |
|---|
| Description | A potent TNFα/TNFRc1 interaction antagonist with IC50 of 50 nM, with no affinity for the related cytokine receptors TNFRc2 or CD40, and no cytotoxicity (>100 uM); also blocks TNF-stimulated phosphorylation of Ikappa-B in Ramos cells (IC50=600 nM) |
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| References | References 1. Carter PH, et al. Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):11879-84. View Related Products by Target TNF-alpha |
| Molecular Formula | C22H23N3O3S2 |
|---|---|
| Molecular Weight | 441.564 |