2172879-52-4
2172879-52-4 structure
- Name: LIT927
- Chemical Name: LIT-927
- CAS Number: 2172879-52-4
- Molecular Formula: C17H13ClN2O3
- Molecular Weight: 328.75
- Catalog: Signaling Pathways GPCR/G Protein CXCR
- Create Date: 2019-01-20 16:51:24
- Modify Date: 2024-02-06 10:49:26
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LIT-927 is a locally and orally active CXCL12 neutraligand with anti-inflammatory effect, with a Ki of 267 nM for CXCL12-TR binding.
| Name | LIT-927 |
|---|
| Description | LIT-927 is a locally and orally active CXCL12 neutraligand with anti-inflammatory effect, with a Ki of 267 nM for CXCL12-TR binding. |
|---|---|
| Related Catalog | |
| Target |
Ki: 267 nM (CXCL12-TR)[1]. |
| In Vitro | LIT-927 is a locally and orally active CXCL12 neutraligand with anti-inflammatory effect, with a Ki of 267 nM for CXCL12-TR binding. Compounds 50, 57 (LIT-927), 65, and 67 are the most potent and soluble cyclic neutraligands identified in vitro and are representative of four novel chemotypes: pyrazoline, pyrimidinone, benzofuranone, and chromanone. LIT-927 is bound to a wide and accessible pocket, which is incompatible with the observed nanomolar binding affinities of our neutraligands[1]. |
| In Vivo | LIT-927 (compound 57) reduces eosinophil recruitment in a murine model of allergic airway hypereosinophilia, LIT-927 is the only one to display inhibitory activity following oral administration. Combined with a high binding selectivity for CXCL12 over other chemokines, LIT-927 represents a powerful pharmacological tool to investigate CXCL12 physiology in vivo and to explore the activity of chemokine neutralization in inflammatory and related diseases[1]. |
| References |
| Molecular Formula | C17H13ClN2O3 |
|---|---|
| Molecular Weight | 328.75 |
| Storage condition | 2-8℃ |