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IW-927

Names

[ CAS No. ]:
389142-48-7

[ Name ]:
IW-927

Biological Activity

[Description]:

A potent TNFα/TNFRc1 interaction antagonist with IC50 of 50 nM, with no affinity for the related cytokine receptors TNFRc2 or CD40, and no cytotoxicity (>100 uM); also blocks TNF-stimulated phosphorylation of Ikappa-B in Ramos cells (IC50=600 nM)

[References]

References 1. Carter PH, et al. Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):11879-84. View Related Products by Target TNF-alpha

Chemical & Physical Properties

[ Molecular Formula ]:
C22H23N3O3S2

[ Molecular Weight ]:
441.564


Related Compounds

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