389142-48-7
389142-48-7 structure
- Name: IW-927
- Chemical Name: IW-927
- CAS Number: 389142-48-7
- Molecular Formula: C22H23N3O3S2
- Molecular Weight: 441.564
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2020-01-12 14:32:50
- Modify Date: 2024-04-05 12:02:32
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A potent TNFα/TNFRc1 interaction antagonist with IC50 of 50 nM, with no affinity for the related cytokine receptors TNFRc2 or CD40, and no cytotoxicity (>100 uM); also blocks TNF-stimulated phosphorylation of Ikappa-B in Ramos cells (IC50=600 nM)
| Name | IW-927 |
|---|
| Description | A potent TNFα/TNFRc1 interaction antagonist with IC50 of 50 nM, with no affinity for the related cytokine receptors TNFRc2 or CD40, and no cytotoxicity (>100 uM); also blocks TNF-stimulated phosphorylation of Ikappa-B in Ramos cells (IC50=600 nM) |
|---|---|
| References | References 1. Carter PH, et al. Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):11879-84. View Related Products by Target TNF-alpha |
| Molecular Formula | C22H23N3O3S2 |
|---|---|
| Molecular Weight | 441.564 |