2-(9-Oxoacridin-10(9H)-yl)acetic acid

Modify Date: 2024-01-13 12:40:40

2-(9-Oxoacridin-10(9H)-yl)acetic acid structure	Common Name	2-(9-Oxoacridin-10(9H)-yl)acetic acid
	CAS Number	38609-97-1	Molecular Weight	253.253
	Density	1.4±0.1 g/cm3	Boiling Point	486.6±34.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₁₁NO₃	Melting Point	-289ºC (dec.)
	MSDS	Chinese USA	Flash Point	248.1±25.7 °C
	Symbol	GHS07	Signal Word	Warning

Use of 2-(9-Oxoacridin-10(9H)-yl)acetic acid

Cridanimod is a small-molecule immunomodulator and interferon inducer[1]. Cridanimod is a potent progesterone receptor (PR) activator mediated through induction of IFNα and IFNβ expression[2].

Name	9-Oxo-10(9H)-acridineacetic acid
Synonym	More Synonyms

Description	Cridanimod is a small-molecule immunomodulator and interferon inducer[1]. Cridanimod is a potent progesterone receptor (PR) activator mediated through induction of IFNα and IFNβ expression[2].
Related Catalog	Signaling Pathways >> Others >> Progesterone Receptor Signaling Pathways >> Immunology/Inflammation >> IFNAR Research Areas >> Inflammation/Immunology
Target	PR, IFNα, IFNβ[1]
In Vivo	Cridanimod (IM; 1-6 mg; twice a week) has a significantly longer survival time. Cridanimod significant increases in IFNα and -β in cridanimod-treated mice in a dose-dependent manner[1]. Animal Model: Athymic mice with hec50co cells[1] Dosage: 1, 3, 6 mg Administration: IM; twice a week Result: Had a significantly longer survival time.
References	[1]. Xenetic Biosciences Announces FDA Acceptance of Investigational New Drug Application to Initiate Phase 2 Clinical Trial of Virexxa® in Endometrial Cancer. AUGUST 19, 2016 [2]. Matthew J. Carlson, et al. Cridanimod and progestin therapy in hormone-resistant endometrial cancer. Journal of Clinical Oncology, January 30, 2017.

Density	1.4±0.1 g/cm3
Boiling Point	486.6±34.0 °C at 760 mmHg
Melting Point	-289ºC (dec.)
Molecular Formula	C₁₅H₁₁NO₃
Molecular Weight	253.253
Flash Point	248.1±25.7 °C
Exact Mass	253.073898
PSA	59.30000
LogP	2.03
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.657

2-(9-Oxoacridin-10(9H)-yl)acetic acid MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AR7190000

CHEMICAL NAME :: 10(9H)-Acridineacetic acid, 9-oxo-

CAS REGISTRY NUMBER :: 38609-97-1

BEILSTEIN REFERENCE NO. :: 0227508

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C15-H11-N-O3

MOLECULAR WEIGHT :: 253.27

WISWESSER LINE NOTATION :: T C666 BN IVJ B1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 1022 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 6,408,1981

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	26
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	AR7190000
HS Code	2933990090

Precursor 9
CAS#:77778-90-6 9-Oxo-10-acridi... CAS#:105-36-2 ethyl 2-bromoacetate CAS#:578-95-0 Acridone CAS#:38609-90-4 Cridanimod ethy...
CAS#:77778-87-1 2-[N-(cyanometh... CAS#:77778-88-2 N-(aminocarbony... CAS#:85793-68-6 2-[N-(carboxyme... CAS#:91-40-7 N-Phenylanthran...
CAS#:118-91-2 2-Chlorobenzoic acid
DownStream 0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

[The interferon production by rat spleen and thymus lymphocytes in condititons of hypoacidity].

Fiziol. Zh. 59(1) , 84-8, (2013)

The interferon production by rat spleen and thymus lymphocytes in conditions of gastric juice hypoacidity, evoked by 28 days of omeprazole treatment, was studied. It was shown that the spontaneous and...

[Experimental justification of approaches to pharmacological correction of delayed disorders caused by acute ethylene glycol poisoning].

Eksp. Klin. Farmakol. 75(11) , 31-4, (2012)

The development of delayed disorders caused by acute ethylene glycol poisoning has been studied in experiments on male rats. These disorders include chronic renal failure and secondary combined immuno...

Species-specific detection of the antiviral small-molecule compound CMA by STING.

EMBO J. 32(10) , 1440-50, (2013)

Extensive research on antiviral small molecules starting in the early 1970s has led to the identification of 10-carboxymethyl-9-acridanone (CMA) as a potent type I interferon (IFN) inducer. Up to date...

cridanimod

(9,10-Dihydro-9-oxo-10-acridinyl)acetic acid

MFCD00157050

(9-Oxo-10(9H)-acridinyl)acetic acid

9-Oxo-10(9H)-acridineacetic acid

(9-oxoacridin-10(9H)-yl)acetic acid

10-(Carboxymethyl)-9(10H)-acridone

2-(9-oxoacridin-10-yl)acetic acid

10(9H)-Acridineacetic acid, 9-oxo-

9-Oxoacridine-10-acetic Acid

10-(Carboxymethyl)-9(10H)acridone

(9,10-Dihydro-9-oxo-10-acridinyl)acetic acid (10-(Carboxymethyl)-9(10H)acridone

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 2-(9-Oxoacridin-10(9H)-yl)acetic acid
Price: ￥638.0/5g ￥178.0/1g
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Cridanimod
Price: $250.0/100mg $500.0/250mg $1000.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 9-Oxo-10(9H)-acridineacetic acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: 9-Oxo-10(9H)-acridineacetic acid
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: TIANFU-CHEM 38609-97-1 9-Oxo-10(9H)-acridineacetic acid
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Price: ￥770/10 mM * 1 mL in DMSO

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2-(9-Oxoacridin-10(9H)-yl)acetic acid

Use of 2-(9-Oxoacridin-10(9H)-yl)acetic acid

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