NSC668394
Modify Date: 2025-09-28 21:01:25
NSC668394 structure
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Common Name | NSC668394 | ||
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| CAS Number | 382605-72-3 | Molecular Weight | 452.097 | |
| Density | 1.9±0.1 g/cm3 | Boiling Point | 575.1±50.0 °C at 760 mmHg | |
| Molecular Formula | C17H12Br2N2O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 301.6±30.1 °C | |
Use of NSC668394NSC668394 (NSC 668394) is a small molecule inhibitor of ezrin, directly bind to ezrin with Kd of 12.59 uM; inhibits T567 phosphorylation and actin binding of endogenous ezrin at 10 μM without altering cellular ezrin levels, inhibits PKC-Ι phosphorylation of recombinant ezrin with IC50 of 8.1 uM; inhibits ezrin-mediated invasion of K7M2 OS cells, inhibits cell motility during zebrafish and Xenopus embryonic development; also inhibits ezrin-dependent in vivo OS metastatic growth in mouse lung. |
| Name | 7-((2-(3,5-dibromo-4-hydroxyphenyl)ethyl)amino)-5,8-quinolinedione |
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| Synonym | More Synonyms |
| Description | NSC668394 (NSC 668394) is a small molecule inhibitor of ezrin, directly bind to ezrin with Kd of 12.59 uM; inhibits T567 phosphorylation and actin binding of endogenous ezrin at 10 μM without altering cellular ezrin levels, inhibits PKC-Ι phosphorylation of recombinant ezrin with IC50 of 8.1 uM; inhibits ezrin-mediated invasion of K7M2 OS cells, inhibits cell motility during zebrafish and Xenopus embryonic development; also inhibits ezrin-dependent in vivo OS metastatic growth in mouse lung. |
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| References | References 1. Bulut G, et al. Oncogene. 2012 Jan 19;31(3):269-81. View Related Products by Target Ezrin |
| Density | 1.9±0.1 g/cm3 |
|---|---|
| Boiling Point | 575.1±50.0 °C at 760 mmHg |
| Molecular Formula | C17H12Br2N2O3 |
| Molecular Weight | 452.097 |
| Flash Point | 301.6±30.1 °C |
| Exact Mass | 449.921448 |
| LogP | 3.65 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.729 |
| InChIKey | OHPHDPYJEHZGDE-UHFFFAOYSA-N |
| SMILES | O=C1C=C(NCCc2cc(Br)c(O)c(Br)c2)C(=O)c2ncccc21 |
| Hazard Codes | Xi |
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| 5,8-Quinolinedione, 7-[[2-(3,5-dibromo-4-hydroxyphenyl)ethyl]amino]- |
| 7-{[2-(3,5-Dibromo-4-hydroxyphenyl)ethyl]amino}-5,8-quinolinedione |
| 7-((2-(3,5-dibromo-4-hydroxyphenyl)ethyl)amino)-5,8-quinolinedione |