NSC668394

Names

[ Name ]:
NSC668394

[Synonym ]:
5,8-Quinolinedione, 7-[[2-(3,5-dibromo-4-hydroxyphenyl)ethyl]amino]-
7-{[2-(3,5-Dibromo-4-hydroxyphenyl)ethyl]amino}-5,8-quinolinedione
7-((2-(3,5-dibromo-4-hydroxyphenyl)ethyl)amino)-5,8-quinolinedione

Biological Activity

[Description]:

NSC668394 (NSC 668394) is a small molecule inhibitor of ezrin, directly bind to ezrin with Kd of 12.59 uM; inhibits T567 phosphorylation and actin binding of endogenous ezrin at 10 μM without altering cellular ezrin levels, inhibits PKC-Ι phosphorylation of recombinant ezrin with IC50 of 8.1 uM; inhibits ezrin-mediated invasion of K7M2 OS cells, inhibits cell motility during zebrafish and Xenopus embryonic development; also inhibits ezrin-dependent in vivo OS metastatic growth in mouse lung.

[References]

References 1. Bulut G, et al. Oncogene. 2012 Jan 19;31(3):269-81. View Related Products by Target Ezrin

Chemical & Physical Properties

[ Density]:
1.9±0.1 g/cm3

[ Boiling Point ]:
575.1±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₂Br₂N₂O₃

[ Molecular Weight ]:
452.097

[ Flash Point ]:
301.6±30.1 °C

[ Exact Mass ]:
449.921448

[ LogP ]:
3.65

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.729

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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