382605-72-3

382605-72-3 structure

Name: NSC668394
Chemical Name: 7-((2-(3,5-dibromo-4-hydroxyphenyl)ethyl)amino)-5,8-quinolinedione
CAS Number: 382605-72-3
Molecular Formula: C₁₇H₁₂Br₂N₂O₃
Molecular Weight: 452.097
Catalog: Research Areas Cancer
Create Date: 2020-01-11 10:42:56
Modify Date: 2024-01-09 21:17:35
NSC668394 (NSC 668394) is a small molecule inhibitor of ezrin, directly bind to ezrin with Kd of 12.59 uM; inhibits T567 phosphorylation and actin binding of endogenous ezrin at 10 μM without altering cellular ezrin levels, inhibits PKC-Ι phosphorylation of recombinant ezrin with IC50 of 8.1 uM; inhibits ezrin-mediated invasion of K7M2 OS cells, inhibits cell motility during zebrafish and Xenopus embryonic development; also inhibits ezrin-dependent in vivo OS metastatic growth in mouse lung.

Name	7-((2-(3,5-dibromo-4-hydroxyphenyl)ethyl)amino)-5,8-quinolinedione
Synonyms	5,8-Quinolinedione, 7-[[2-(3,5-dibromo-4-hydroxyphenyl)ethyl]amino]- 7-{[2-(3,5-Dibromo-4-hydroxyphenyl)ethyl]amino}-5,8-quinolinedione 7-((2-(3,5-dibromo-4-hydroxyphenyl)ethyl)amino)-5,8-quinolinedione

Description	NSC668394 (NSC 668394) is a small molecule inhibitor of ezrin, directly bind to ezrin with Kd of 12.59 uM; inhibits T567 phosphorylation and actin binding of endogenous ezrin at 10 μM without altering cellular ezrin levels, inhibits PKC-Ι phosphorylation of recombinant ezrin with IC50 of 8.1 uM; inhibits ezrin-mediated invasion of K7M2 OS cells, inhibits cell motility during zebrafish and Xenopus embryonic development; also inhibits ezrin-dependent in vivo OS metastatic growth in mouse lung.
References	References 1. Bulut G, et al. Oncogene. 2012 Jan 19;31(3):269-81. View Related Products by Target Ezrin

Hazard Codes	Xi