4-Methylumbelliferyl-N-acetyl-ß-D-glucosaminide

Modify Date: 2025-08-22 14:52:25

4-Methylumbelliferyl-N-acetyl-ß-D-glucosaminide Structure
4-Methylumbelliferyl-N-acetyl-ß-D-glucosaminide structure
 Common Name 4-Methylumbelliferyl-N-acetyl-ß-D-glucosaminide
CAS Number 37067-30-4 Molecular Weight 379.361
Density 1.5±0.1 g/cm3 Boiling Point 732.2±60.0 °C at 760 mmHg
Molecular Formula C18H21NO8 Melting Point 208-210 °C
MSDS Chinese USA Flash Point 396.6±32.9 °C

 Use of 4-Methylumbelliferyl-N-acetyl-ß-D-glucosaminide


4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-Glucopyranoside is a fluorogenic substrate for N-acetyl-β-D-glucosaminidase[1].

 Names

Name 4-METHYLUMBELLIFERYL-N-ACETYL-β-D-GLUCOSAMINIDE
Synonym More Synonyms

  Biological Activity

Description 4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-Glucopyranoside is a fluorogenic substrate for N-acetyl-β-D-glucosaminidase[1].
Related Catalog
In Vitro The enzyme functionality is assessed by its ability remove terminal β-glycosidically bound N-acetylglucosamine and N-acetylgalactosamine residues from 4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-Glucopyranoside[1].
References

[1]. Li J, et, al. Identification of a specific inhibitor of nOGA - a caspase-3 cleaved O-GlcNAcase variant during apoptosis. Biochemistry (Mosc). 2012 Feb;77(2):194-200.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 732.2±60.0 °C at 760 mmHg
Melting Point 208-210 °C
Molecular Formula C18H21NO8
Molecular Weight 379.361
Flash Point 396.6±32.9 °C
Exact Mass 379.126709
PSA 138.46000
LogP 0.34
Vapour Pressure 0.0±2.5 mmHg at 25°C
Index of Refraction 1.632
Storage condition −20°C
Stability Light Sensitive - Protect from Light
Water Solubility DMF: 20 mg/mL, clear, colorless

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xn
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3

 Synthetic Route

(2R,3S,4R,5R,6S)-5-ACETAMIDO-2-(ACETOXYMETHYL)-6-((4-METHYL-2-OXO-2H-CHROMEN-7-YL)OXY)TETRAHYDRO-2H-PYRAN-3,4-DIYL DIACETATE structure

(2R,3S,4R,5R,6S...

CAS#:38971-29-8

~96%

4-Methylumbelliferyl-N-acetyl-ß-D-glucosaminide Structure

4-Methylumbelli...

CAS#:37067-30-4

Literature: Carbohydrate Research, , vol. 346, # 12 p. 1467 - 1478
4-Methylumbelliferone structure

4-Methylumbelli...

CAS#:90-33-5

~%

4-Methylumbelliferyl-N-acetyl-ß-D-glucosaminide Structure

4-Methylumbelli...

CAS#:37067-30-4

Literature: Carbohydrate Research, , vol. 346, # 12 p. 1467 - 1478
2-acetamido-2-deoxy-alpha-D-glucopyranosyl chloride 3,4,6-triacetate structure

2-acetamido-2-d...

CAS#:3068-34-6

~%

4-Methylumbelliferyl-N-acetyl-ß-D-glucosaminide Structure

4-Methylumbelli...

CAS#:37067-30-4

Literature: Carbohydrate Research, , vol. 346, # 12 p. 1467 - 1478
4-methylumbelliferyl-n,n',n''-triacetyl-beta-chitotrioside structure

4-methylumbelli...

CAS#:53643-13-3

~%

N/A structure

N/A

CAS#:14200-67-0

4-Methylumbelliferyl-N-acetyl-ß-D-glucosaminide Structure

4-Methylumbelli...

CAS#:37067-30-4

Literature: Bioscience, Biotechnology and Biochemistry, , vol. 72, # 3 p. 715 - 723

 Articles27

More Articles
Tay-Sachs disease heterozygote detection: use of a centrifugal analyser for automation of hexosaminidase assays with two different artificial substrates.

J. Med. Genet. 28(2) , 101-9, (1991)

An assay for measuring hexosaminidase A in serum and leucocytes is described in which a centrifugal analyser is used for automation of the enzyme assays after manual heat inactivation. The assay was u...

TNFalpha-induced macrophage death via caspase-dependent and independent pathways.

Apoptosis 14(3) , 320-32, (2009)

Macrophages are the principal source of TNFalpha, yet they are highly resistant to TNFalpha-mediated cell death. Previously, employing in vitro differentiated human macrophages, we showed that followi...

A rapid method for detection of N-acetylglucosaminidase-type chitinase activity in crossed immunoelectrophoresis and sodium dodecyl sulfate-polyacrylamide gel electrophoresis gels using 4-methylumbelliferyl-N-acetyl-D-glucosaminide as substrate.

Electrophoresis 15(5) , 662-5, (1994)

A method for the detection of N-acetylglucosaminidase (GlcNAcase) activity has been developed by using 4-methyl-umbelliferyl-N-acetyl-D-glucosaminide (4-MU-GlcNAc) as substrate in crossed immunoelectr...

 Synonyms

4-Methyl-2-oxo-2H-chromen-7-yl 2-acetamido-2-deoxy-β-D-glucopyranoside
4-Methylumbelliferyl 2-Acetamido-2-deoxy-β-D-glucopyranoside
GLCNAC1-B-4MU
MFCD00065481
4-Methylumbelliferyl-N-acetyl-ß-D-glucosaminide
4-Methylumbelliferyl-N-acetyl-β-D-glucosaminide
7-((2-Acetamido-2-deoxy-β-D-glucopyranosyl)oxy)-4-methyl-2H-1-benzopyran-2-one
EINECS 253-333-0
Methylumbelliferyl-N-acetyl-b-D-glucosaminide
2H-1-Benzopyran-2-one, 7-[[2-(acetylamino)-2-deoxy-β-D-glucopyranosyl]oxy]-4-methyl-
T66 BOVJ E1 IO- BT6OTJ CMV1 DQ EQ F1Q &&β-D-Gluco Form
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Chemsrc provides CAS#:37067-30-4 MSDS, density, melting point, boiling point, structure, etc. Its name is 4-Methylumbelliferyl-N-acetyl-ß-D-glucosaminide>> amp version: 4-Methylumbelliferyl-N-acetyl-ß-D-glucosaminide

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