oxalic bis(cyclohexylidenehydrazide)

Modify Date: 2025-08-19 18:23:52

oxalic bis(cyclohexylidenehydrazide) structure	Common Name	oxalic bis(cyclohexylidenehydrazide)
	CAS Number	370-81-0	Molecular Weight	278.350
	Density	1.3±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₄H₂₂N₄O₂	Melting Point	210-214 °C(lit.)
	MSDS	Chinese USA	Flash Point	N/A

Use of oxalic bis(cyclohexylidenehydrazide)

Cuprizone is a chelator used as a reagent for copper analysis. Cuprizone is frequently used for studying factors that affect oligodendrocytes death and myelin loss[1][2].

Name	Bis(cyclohexanone)oxaldihydrazone
Synonym	More Synonyms

Description	Cuprizone is a chelator used as a reagent for copper analysis. Cuprizone is frequently used for studying factors that affect oligodendrocytes death and myelin loss[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vivo	Cuprizone (0.5 mg/100 mg of diet and water given ad lib; p.o.) produces severe status spongious in the CNS, most prominently in the brain stem and cerebellar white matter of mice[1].
References	[1]. Suzuki K, et al. Status spongiosus of CNS and hepatic changes induced by cuprizone (biscyclohexanone oxalyldihydrazone). Am J Pathol. 1969 Feb;54(2):307-25. [2]. Sanadgol N, et al. Alpha-lipoic acid mitigates toxic-induced demyelination in the corpus callosum by lessening of oxidative stress and stimulation of polydendrocytes proliferation. Metab Brain Dis. 2018 Feb;33(1):27-37.

Density	1.3±0.1 g/cm3
Melting Point	210-214 °C(lit.)
Molecular Formula	C₁₄H₂₂N₄O₂
Molecular Weight	278.350
Exact Mass	278.174286
PSA	82.92000
LogP	0.85
Index of Refraction	1.626
Storage condition	2-8°C

oxalic bis(cyclohexylidenehydrazide) MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RO2520000

CHEMICAL NAME :: Oxalic acid, bis(cyclohexylidenehydrazide)

CAS REGISTRY NUMBER :: 370-81-0

BEILSTEIN REFERENCE NO. :: 2388004

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C14-H22-N4-O2

MOLECULAR WEIGHT :: 278.40

WISWESSER LINE NOTATION :: L6YTJ AUNMVVMNU- AL6YTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 29400 mg/kg/7W-C

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20160 mg/kg/8W-C

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - monoamine oxidase

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 24 gm/kg

SEX/DURATION :: female 3-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - live birth index (measured after birth)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 40 gm/kg

SEX/DURATION :: female 3-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - stillbirth

MUTATION DATA

TEST SYSTEM :: Rodent - rat

DOSE/DURATION :: 14 gm/kg/14D (Continuous)

REFERENCE :: EJBCAI European Journal of Biochemistry. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1967- Volume(issue)/page/year: 47,313,1974

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn:Harmful;
Risk Phrases	R21/22
Safety Phrases	S24/25-S2
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	RO2520000
Packaging Group	I; II; III
Hazard Class	6.1
HS Code	29280090

Ethanedihydrazide

CAS#:996-98-5

Cyclohexanone

CAS#:108-94-1

oxalic bis(cycl...

CAS#:370-81-0

Literature: Peterson; Bollier Analytical Chemistry, 1955 , vol. 27, p. 1195 Full Text View citing articles Show Details Vanghelovici et al. Acad. Timisoara Stud. Cerc. med., 1962 , vol. 9, p. 143,147

Precursor 2
CAS#:996-98-5 Ethanedihydrazide CAS#:108-94-1 Cyclohexanone
DownStream 0

HS Code	2928000090
Summary	2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

Effect of high-dose 1.25 dihydroxyvitamin D3 on remyelination in the cuprizone model.

APMIS 122(12) , 1178-86, (2014)

Vitamin D supplementation is increasingly recommended to patients with multiple sclerosis (MS). To study the effect of high-dose vitamin D on remyelination, female C57Bl/6 mice were demyelinated with ...

Behavioural changes observed in demyelination model shares similarities with white matter abnormalities in humans.

Behav. Brain Res. 287 , 265-75, (2015)

Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating disease of the central nervous system (CNS). Further to the symptoms resulting from demyelination, new studies point to the involvemen...

Prion protein and copper cooperatively protect neurons by modulating NMDA receptor through S-nitrosylation.

Antioxid. Redox Signal. 22(9) , 772-84, (2015)

Several neurodegenerative disorders show alterations in glutamatergic synapses and increased susceptibility to excitotoxicity. Mounting evidence suggests a central role for the cellular prion protein ...

Dicyclohexanoneoxaly dihydrazone

MFCD00001659

Bis(cyclohexanone) Oxalyldihydrazone

oxalic bis(cyclohexylidenehydrazide)

N,N'-bis(cyclohexylideneamino)oxamide

Oxalic acid bis(cyclohexylidenehydrazide)

Ethanedioic acid, bis(2-cyclohexylidenehydrazide)

Cuprizon,Cuprizone,Oxalic acid bis(cyclohexylidenehydrazide)

N',N'-Dicyclohexylideneethanedihydrazide

Bis(cyclohexanone)oxalyldihydrazone

Cupferazone

Oxalic Acid Bis-(Cyclohexylidenehydrazide)

EINECS 206-729-2

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: oxalic bis(cyclohexylidenehydrazide)
Price: Check
Purity: 99.0%
Delivery: 10 Day
Contact: Yang
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: oxalic bis(cyclohexylidenehydrazide)
Price: ￥68.0/25g ￥128.0/25g
Purity: 98.0%
Delivery: 3 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: Cuprizone
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Delivery: 10 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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Use of oxalic bis(cyclohexylidenehydrazide)

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