SMPH Crosslinker

Modify Date: 2024-01-10 23:01:10

SMPH Crosslinker Structure
SMPH Crosslinker structure
Common Name SMPH Crosslinker
CAS Number 367927-39-7 Molecular Weight 379.36500
Density N/A Boiling Point N/A
Molecular Formula C17H21N3O7 Melting Point N/A
MSDS Chinese USA Flash Point N/A

 Use of SMPH Crosslinker


SMPH Crosslinker is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name N-Succinimidyl 6-(3-Maleimidopropionamido) Hexanoate
Synonym More Synonyms

 SMPH Crosslinker Biological Activity

Description SMPH Crosslinker is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C17H21N3O7
Molecular Weight 379.36500
Exact Mass 379.13800
PSA 130.16000

 Precursor & DownStream

Precursor  2

DownStream  0

 Synonyms

(2,5-dioxopyrrolidin-1-yl) 6-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]hexanoate
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