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367927-39-7

367927-39-7 structure
367927-39-7 structure
  • Name: SMPH Crosslinker
  • Chemical Name: N-Succinimidyl 6-(3-Maleimidopropionamido) Hexanoate
  • CAS Number: 367927-39-7
  • Molecular Formula: C17H21N3O7
  • Molecular Weight: 379.36500
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2017-10-23 08:28:11
  • Modify Date: 2024-01-10 23:01:10
  • SMPH Crosslinker is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name N-Succinimidyl 6-(3-Maleimidopropionamido) Hexanoate
Synonyms (2,5-dioxopyrrolidin-1-yl) 6-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]hexanoate
Description SMPH Crosslinker is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Molecular Formula C17H21N3O7
Molecular Weight 379.36500
Exact Mass 379.13800
PSA 130.16000
Precursor  2

DownStream  0