4-Hydroxy-2,5-dimethylfuran-3(2H)-one

Modify Date: 2025-08-20 19:26:57

4-Hydroxy-2,5-dimethylfuran-3(2H)-one Structure
4-Hydroxy-2,5-dimethylfuran-3(2H)-one structure
 Common Name 4-Hydroxy-2,5-dimethylfuran-3(2H)-one
CAS Number 3658-77-3 Molecular Weight 128.126
Density 1.3±0.1 g/cm3 Boiling Point 215.5±40.0 °C at 760 mmHg
Molecular Formula C6H8O3 Melting Point 73-77 °C(lit.)
MSDS Chinese USA Flash Point 90.5±20.8 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of 4-Hydroxy-2,5-dimethylfuran-3(2H)-one


Furaneol is mainly isolated from American grape (Vitis labrusca) and its hybrid grape. Furaneol is an important aroma compound in fruits and contribute to the strawberry-like note in some wines[1].

 Names

Name 4-hydroxy-2,5-dimethylfuran-3-one
Synonym More Synonyms

 4-Hydroxy-2,5-dimethylfuran-3(2H)-one Biological Activity

Description Furaneol is mainly isolated from American grape (Vitis labrusca) and its hybrid grape. Furaneol is an important aroma compound in fruits and contribute to the strawberry-like note in some wines[1].
Related Catalog
References

[1]. Sasaki K, et al. Molecular cloning and characterization of UDP-glucose: furaneol glucosyltransferase gene from grapevine cultivar Muscat Bailey A (Vitis labrusca × V. vinifera. J Exp Bot. 2015 Oct;66(20):6167-74.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 215.5±40.0 °C at 760 mmHg
Melting Point 73-77 °C(lit.)
Molecular Formula C6H8O3
Molecular Weight 128.126
Flash Point 90.5±20.8 °C
Exact Mass 128.047348
PSA 46.53000
LogP 0.34
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.513
Storage condition 2-8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LU3990000
CHEMICAL NAME :
3(2H)-Furanone, 2,5-dimethyl-4-hydroxy-
CAS REGISTRY NUMBER :
3658-77-3
LAST UPDATED :
199701
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C6-H8-O3
MOLECULAR WEIGHT :
128.14

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1608 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
Micronucleus test
TYPE OF TEST :
Sister chromatid exchange

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
DOSE/DURATION :
232 mg/kg
REFERENCE :
CHYCDW Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) Beginning history not known. Volume(issue)/page/year: 22,85,1988

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Personal Protective Equipment Eyeshields;Faceshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)
Hazard Codes Xn:Harmful;
Risk Phrases R22
Safety Phrases S36-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS LU3990000
HS Code 2932190090

 Synthetic Route

 Customs

HS Code 2932190090
Summary 2932190090 other compounds containing an unfused furan ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

 Articles32

More Articles
Odorants in breast milk.

Arch. Pediatr. Adolesc. Med. 157(10) , 1031, (2003)

Structural basis for the enzymatic formation of the key strawberry flavor compound 4-hydroxy-2,5-dimethyl-3(2H)-furanone.

J. Biol. Chem. 288(23) , 16815-26, (2013)

The last step in the biosynthetic route to the key strawberry flavor compound 4-hydroxy-2,5-dimethyl-3(2H)-furanone (HDMF) is catalyzed by Fragaria x ananassa enone oxidoreductase (FaEO), earlier puta...

Characterization of the key aroma compounds in soy sauce using approaches of molecular sensory science.

J. Agric. Food Chem. 55(15) , 6262-9, (2007)

Application of aroma extract dilution analysis (AEDA) to the volatiles isolated from a commercial Japanese soy sauce revealed 30 odor-active compounds in the flavor dilution (FD) factor range of 8-409...

 Synonyms

2,5-DiMethyl-4-hydroxy-3(2H)-furanone
CARMELAN
FEMA 3174
4-hydroxy-2,5-dimethyl-3-oxo-2H-furan
Pineapple ketone
4-Hydroxy-2,5-dimethylfuran-2(3H)-one
EINECS 222-908-8
T5OJ B1 CQ DQ E1
4-Hydroxy-2,5-dimethyl-3-furanone
Strawberry furanone
4-Hydroxy-2,5-dimethyl-3(2H)furanone
2,5-dimethyl-4-hydroxy-2H-furan-3-one
Dimethylhydroxy furanone
2,5-Dimethyl-4-hydroxy-3(2H)-furanone,Furaneol,Strawberry furanone
2,5-dimethyl-4-hydroxy-2,3-dihydrofuran-3-one
Alletone
Furaneol
4-Hydroxy-2,5-dimethylfuran-3(2H)-one
2,4-DIMETHYLBENZENEBORONIC ACID
T5O CV BHJ B1 DQ E1
4-oxo-3-hydroxy-2,5-dimethyl-4,5-dihydrofuran
HDMF
RI-2024
3(2H)-Furanone, 4-hydroxy-2,5-dimethyl-
4-Hydroxy-2,5-dimethyl-3(2H)-furanone
MFCD00010706
T5VV DOTJ C1 E1
COE 536
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Chemsrc provides 4-Hydroxy-2,5-dimethylfuran-3(2H)-one(CAS#:3658-77-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of 4-Hydroxy-2,5-dimethylfuran-3(2H)-one are included as well.>> amp version: 4-Hydroxy-2,5-dimethylfuran-3(2H)-one

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