| Description |
Oxantel (CP-14445), a m-oxyphenol derivative of Pyrantel (HY-12641), is a N-subtype AChR agonist. Oxantel is an anthelmintic, with excellent trichuricidal properties[1][2].
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| Related Catalog |
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| Target |
nAChR[1][2]
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| In Vitro |
Oxantel ( 0.015-600 µg/mL; 24-72 hours) reduces the viability of T. muris[1]. Cell Viability Assay Cell Line: T. muris Concentration: 0.015 µg/mL, 0.3 µg/mL, 0.6 µg/mL, 4.66 µg/mL, 9.375 µg/mL, 150 µg/mL, 600 µg/mL Incubation Time: 24 hours, 48 hours, 72 hours Result: Resulted in strongly reduced viabilities; resulted in strongly reduced viabilities within 24 hours but did not kill the worms.
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| In Vivo |
Oxantel (1-10 mg/kg; i.p.) displays a high activity against T. muris in vivo, with an EC50 of 4.71 mg/kg[1]. Oxantel (10 mg/kg; i.p.) exhibits a worm burden reduction (WBR) of 92.5% and worm expulsion rate (WER) of 88.4% for T. muris[1]. Animal Model: 4 week-old female C57BL/10 mice and 3 week-old male[1] Dosage: 1 mg/kg, 2.5 mg/kg, 5 mg/kg, 10 mg/kg Administration: Intraperitoneal injection Result: Inhibited T. muris in vivo.
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| References |
[1]. Richard J Martin, et al. Oxantel is an N-type (methyridine and nicotine) agonist not an L-type (levamisole and pyrantel) agonist: classification of cholinergic anthelmintics in Ascaris. Int J Parasitol. 2004 Aug;34(9):1083-90. [2]. V M Dale, et al. Oxantel-activated single channel currents in the muscle membrane of Ascaris suum. Parasitology. 1995 May;110 ( Pt 4):437-48.
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