RIPGBM structure
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Common Name | RIPGBM | ||
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CAS Number | 355406-76-7 | Molecular Weight | 428.45 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C26H21FN2O3 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of RIPGBMRIPGBM is a selective inducer of apoptosis in glioblastoma multiforme (GBM) cancer stem cells (CSCs) with an EC50 of ≤500 nM[1]. |
Name | RIPGBM |
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Description | RIPGBM is a selective inducer of apoptosis in glioblastoma multiforme (GBM) cancer stem cells (CSCs) with an EC50 of ≤500 nM[1]. |
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Related Catalog | |
Target |
EC50: ≤500 nM (Apoptosis, in GBM CSCs)[1] |
In Vitro | RIPGBM induces caspase 1-dependent apoptosis by binding to receptor-interacting protein kinase 2 (RIPK2) and acting as a molecular switch, which reduces the formation of a prosurvival RIPK2/ TAK1 complex and increases the formation of a proapoptotic RIPK2/caspase 1 complex[1]. |
References |
Molecular Formula | C26H21FN2O3 |
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Molecular Weight | 428.45 |
Hazard Codes | Xi |
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