RIPGBM

Names

[ Name ]:
RIPGBM

Biological Activity

[Description]:

RIPGBM is a selective inducer of apoptosis in glioblastoma multiforme (GBM) cancer stem cells (CSCs) with an EC50 of ≤500 nM[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

[Target]

EC50: ≤500 nM (Apoptosis, in GBM CSCs)[1]

[In Vitro]

RIPGBM induces caspase 1-dependent apoptosis by binding to receptor-interacting protein kinase 2 (RIPK2) and acting as a molecular switch, which reduces the formation of a prosurvival RIPK2/ TAK1 complex and increases the formation of a proapoptotic RIPK2/caspase 1 complex[1].

[References]

[1]. Lucki NC, et al. A cell type-selective apoptosis-inducing small molecule for the treatment of brain cancer. Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6435-6440.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₂₁FN₂O₃

[ Molecular Weight ]:
428.45

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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