355406-76-7
355406-76-7 structure
- Name: RIPGBM
- Chemical Name: RIPGBM
- CAS Number: 355406-76-7
- Molecular Formula: C26H21FN2O3
- Molecular Weight: 428.45
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2019-06-01 19:13:56
- Modify Date: 2024-01-05 18:07:48
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RIPGBM is a selective inducer of apoptosis in glioblastoma multiforme (GBM) cancer stem cells (CSCs) with an EC50 of ≤500 nM[1].
| Name | RIPGBM |
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| Description | RIPGBM is a selective inducer of apoptosis in glioblastoma multiforme (GBM) cancer stem cells (CSCs) with an EC50 of ≤500 nM[1]. |
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| Related Catalog | |
| Target |
EC50: ≤500 nM (Apoptosis, in GBM CSCs)[1] |
| In Vitro | RIPGBM induces caspase 1-dependent apoptosis by binding to receptor-interacting protein kinase 2 (RIPK2) and acting as a molecular switch, which reduces the formation of a prosurvival RIPK2/ TAK1 complex and increases the formation of a proapoptotic RIPK2/caspase 1 complex[1]. |
| References |
| Molecular Formula | C26H21FN2O3 |
|---|---|
| Molecular Weight | 428.45 |
| Hazard Codes | Xi |
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