5-Nitro-α-oxo-N-(1R)-phenylethyl]-1H-indole-3-acetamide

Modify Date: 2025-08-20 18:37:20

5-Nitro-α-oxo-N-(1R)-phenylethyl]-1H-indole-3-acetamide structure	Common Name	5-Nitro-α-oxo-N-(1R)-phenylethyl]-1H-indole-3-acetamide
	CAS Number	355022-97-8	Molecular Weight	337.32900
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₁₅N₃O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 5-Nitro-α-oxo-N-(1R)-phenylethyl]-1H-indole-3-acetamide

Anxiolytic/nonsedative agent-1 (compound 2b) is a potent and selective GABAA agonist. Anxiolytic/nonsedative agent-1 shows appreciable affinity for the BzR in bovine brain membranes with Kis of 14, 121, 239 nM for α1β2γ2, α2β2γ2, α5β3γ2, respectively. Anxiolytic/nonsedative agent-1 shows α2 selective efficacy in vitro and anxioselective effects in vivo[1].

Name	2-(5-Nitro-1H-indol-3-yl)-2-oxo-N-[(1R)-1-phenylethyl]acetamide

Description	Anxiolytic/nonsedative agent-1 (compound 2b) is a potent and selective GABAA agonist. Anxiolytic/nonsedative agent-1 shows appreciable affinity for the BzR in bovine brain membranes with Kis of 14, 121, 239 nM for α1β2γ2, α2β2γ2, α5β3γ2, respectively. Anxiolytic/nonsedative agent-1 shows α2 selective efficacy in vitro and anxioselective effects in vivo[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
References	[1]. Taliani S, et al. Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the gamma-aminobutyric acid-A (GABAA) alpha2 benzodiazepine receptor. J Med Chem. 2009 Jun 25;52(12):3723-34.

Molecular Formula	C₁₈H₁₅N₃O₄
Molecular Weight	337.32900
Exact Mass	337.10600
PSA	107.78000
LogP	4.05030

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 5-Nitro-α-oxo-N-(1R)-phenylethyl]-1H-indole-3-acetamide
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 5-Nitro-α-oxo-N-(1R)-phenylethyl]-1H-indole-3-acetamide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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Contact: Ms Wang
Email: enquiry@dycnchem.com

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Use of 5-Nitro-α-oxo-N-(1R)-phenylethyl]-1H-indole-3-acetamide

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