5-Nitro-α-oxo-N-(1R)-phenylethyl]-1H-indole-3-acetamide

Names

[ Name ]:
5-Nitro-α-oxo-N-(1R)-phenylethyl]-1H-indole-3-acetamide

Biological Activity

[Description]:

Anxiolytic/nonsedative agent-1 (compound 2b) is a potent and selective GABAA agonist. Anxiolytic/nonsedative agent-1 shows appreciable affinity for the BzR in bovine brain membranes with Kis of 14, 121, 239 nM for α1β2γ2, α2β2γ2, α5β3γ2, respectively. Anxiolytic/nonsedative agent-1 shows α2 selective efficacy in vitro and anxioselective effects in vivo[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[References]

[1]. Taliani S, et al. Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the gamma-aminobutyric acid-A (GABAA) alpha2 benzodiazepine receptor. J Med Chem. 2009 Jun 25;52(12):3723-34.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₅N₃O₄

[ Molecular Weight ]:
337.32900

[ Exact Mass ]:
337.10600

[ PSA ]:
107.78000

[ LogP ]:
4.05030

Related Compounds

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