Bis-tris methane

Modify Date: 2024-01-10 11:18:33

Bis-tris methane Structure
Bis-tris methane structure
Common Name Bis-tris methane
CAS Number 352534-93-1 Molecular Weight 209.240
Density 1.3±0.1 g/cm3 Boiling Point 466.2±40.0 °C at 760 mmHg
Molecular Formula C8H19NO5 Melting Point N/A
MSDS Chinese USA Flash Point 288.0±26.0 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of Bis-tris methane


Bis-Tris-d19 is the deuterium labeled Bis-Tris[1]. Bis-Tris is a commonly used buffer[2].

 Names

Name 1,1,3,3-tetradeuterio-1,3-dideuteriooxy-2-[dideuterio(deuteriooxy)methyl]-N,N-bis(1,1,2,2-tetradeuterio-2-deuteriooxyethyl)propan-2-amine
Synonym More Synonyms

 Bis-tris methane Biological Activity

Description Bis-Tris-d19 is the deuterium labeled Bis-Tris[1]. Bis-Tris is a commonly used buffer[2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Oh, Soon Jin, et al. Structure and phosphodiesterase activity of Bis-Tris coordinated lanthanide(III) complexes.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 466.2±40.0 °C at 760 mmHg
Molecular Formula C8H19NO5
Molecular Weight 209.240
Flash Point 288.0±26.0 °C
Exact Mass 209.126328
PSA 104.39000
LogP -0.67
Vapour Pressure 0.0±2.6 mmHg at 25°C
Index of Refraction 1.563

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
RIDADR NONH for all modes of transport

 Synonyms

2,2-Bis(hydroxymethyl)-2,2',2''-nitilotriethanol
Bis-tris methane
2-[Bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)-1,3-propanediol
2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)propane-1,3-diol
2-(Bis(2-hydroxyethyl)amino)-2-(hydroxymethyl)propane-1,3-diol
1,3-Propanediol, 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)-
Bis-tris-d19
2,2-bis(hydroxymethyl)-2,2′,2″-nitrilotriethanol
2-[Bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)propan-1,3-diol
BIS-TRIS
Bis(2-hydroxyethyl)imino-tris(hydroxymethyl)propane
Bis(2-hydroxyethyl)amino-tris(hydroxymethyl)methane
2,2-Bis(hydroxymethyl)-2,2',2"-nitrilotriethanol