352534-93-1

352534-93-1 structure

352534-93-1 structure

Name: Bis-tris methane
Chemical Name: 1,1,3,3-tetradeuterio-1,3-dideuteriooxy-2-[dideuterio(deuteriooxy)methyl]-N,N-bis(1,1,2,2-tetradeuterio-2-deuteriooxyethyl)propan-2-amine
CAS Number: 352534-93-1
Molecular Formula: C₈H₁₉NO₅
Molecular Weight: 209.240
Catalog: Research Areas Others
Create Date: 2018-12-01 05:06:37
Modify Date: 2024-01-10 11:18:33
Bis-Tris-d19 is the deuterium labeled Bis-Tris[1]. Bis-Tris is a commonly used buffer[2].

Name	1,1,3,3-tetradeuterio-1,3-dideuteriooxy-2-[dideuterio(deuteriooxy)methyl]-N,N-bis(1,1,2,2-tetradeuterio-2-deuteriooxyethyl)propan-2-amine
Synonyms	2,2-Bis(hydroxymethyl)-2,2',2''-nitilotriethanol Bis-tris methane 2-[Bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)-1,3-propanediol 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)propane-1,3-diol 2-(Bis(2-hydroxyethyl)amino)-2-(hydroxymethyl)propane-1,3-diol 1,3-Propanediol, 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)- Bis-tris-d19 2,2-bis(hydroxymethyl)-2,2′,2″-nitrilotriethanol 2-[Bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)propan-1,3-diol BIS-TRIS Bis(2-hydroxyethyl)imino-tris(hydroxymethyl)propane Bis(2-hydroxyethyl)amino-tris(hydroxymethyl)methane 2,2-Bis(hydroxymethyl)-2,2',2"-nitrilotriethanol

Description	Bis-Tris-d19 is the deuterium labeled Bis-Tris[1]. Bis-Tris is a commonly used buffer[2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Oh, Soon Jin, et al. Structure and phosphodiesterase activity of Bis-Tris coordinated lanthanide(III) complexes.

Density	1.3±0.1 g/cm3
Boiling Point	466.2±40.0 °C at 760 mmHg
Molecular Formula	C₈H₁₉NO₅
Molecular Weight	209.240
Flash Point	288.0±26.0 °C
Exact Mass	209.126328
PSA	104.39000
LogP	-0.67
Vapour Pressure	0.0±2.6 mmHg at 25°C
Index of Refraction	1.563

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
RIDADR	NONH for all modes of transport