Z-Gly-Gly-Phe-chloromethylketone

Modify Date: 2024-01-12 07:27:19

Z-Gly-Gly-Phe-chloromethylketone Structure
Z-Gly-Gly-Phe-chloromethylketone structure
Common Name Z-Gly-Gly-Phe-chloromethylketone
CAS Number 35172-59-9 Molecular Weight 445.90
Density N/A Boiling Point N/A
Molecular Formula C22H24ClN3O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Z-Gly-Gly-Phe-chloromethylketone


Z-GGF-CMK is a protease inhibitor, inhibits ClpP1P2 and proteasome. Z-GGF-CMK exhibits cytotoxic activity against HepG2 cells with a CC50 value of 125 μM[1].

 Names

Name benzyl N-[2-[[2-[[(2S)-4-chloro-3-oxo-1-phenylbutan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]carbamate
Synonym More Synonyms

 Z-Gly-Gly-Phe-chloromethylketone Biological Activity

Description Z-GGF-CMK is a protease inhibitor, inhibits ClpP1P2 and proteasome. Z-GGF-CMK exhibits cytotoxic activity against HepG2 cells with a CC50 value of 125 μM[1].
Related Catalog
References

[1]. Moreira W, et, al. Bortezomib Warhead-Switch Confers Dual Activity against Mycobacterial Caseinolytic Protease and Proteasome and Selectivity against Human Proteasome. Front Microbiol. 2017 Apr 27;8:746.  

 Chemical & Physical Properties

Molecular Formula C22H24ClN3O5
Molecular Weight 445.90
Exact Mass 445.14000
PSA 113.60000
LogP 2.73710

 Synonyms

Z-Gly-Gly-Phe chloromethyl ketone
Z-Gly-Gly-Phe-chloromethylketone