35172-59-9

35172-59-9 structure

Name: Z-Gly-Gly-Phe-chloromethylketone
Chemical Name: benzyl N-[2-[[2-[[(2S)-4-chloro-3-oxo-1-phenylbutan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]carbamate
CAS Number: 35172-59-9
Molecular Formula: C₂₂H₂₄ClN₃O₅
Molecular Weight: 445.90
Catalog: Signaling Pathways Metabolic Enzyme/Protease Proteasome
Create Date: 2018-12-28 06:55:37
Modify Date: 2025-09-21 12:29:02
Z-GGF-CMK is a protease inhibitor, inhibits ClpP1P2 and proteasome. Z-GGF-CMK exhibits cytotoxic activity against HepG2 cells with a CC50 value of 125 μM[1].

Name	benzyl N-[2-[[2-[[(2S)-4-chloro-3-oxo-1-phenylbutan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]carbamate
Synonyms	Z-Gly-Gly-Phe chloromethyl ketone Z-Gly-Gly-Phe-chloromethylketone

Description	Z-GGF-CMK is a protease inhibitor, inhibits ClpP1P2 and proteasome. Z-GGF-CMK exhibits cytotoxic activity against HepG2 cells with a CC50 value of 125 μM[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome
References	[1]. Moreira W, et, al. Bortezomib Warhead-Switch Confers Dual Activity against Mycobacterial Caseinolytic Protease and Proteasome and Selectivity against Human Proteasome. Front Microbiol. 2017 Apr 27;8:746.