1,1,3-Tribromoacetone

Modify Date: 2025-08-20 11:54:56

1,1,3-Tribromoacetone Structure
1,1,3-Tribromoacetone structure
 Common Name 1,1,3-Tribromoacetone
CAS Number 3475-39-6 Molecular Weight 294.767
Density 2.6±0.1 g/cm3 Boiling Point 266.2±25.0 °C at 760 mmHg
Molecular Formula C3H3Br3O Melting Point N/A
MSDS N/A Flash Point 115.1±9.7 °C

 Use of 1,1,3-Tribromoacetone


1,1,3-Tribromoacetone is an impurity of methotrexate[1]. Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis[1].

 Names

Name 1,1,3-tribromopropan-2-one
Synonym More Synonyms

 1,1,3-Tribromoacetone Biological Activity

Description 1,1,3-Tribromoacetone is an impurity of methotrexate[1]. Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis[1].
Related Catalog
In Vivo Methotrexate (Amethopterin) reduces thymus and spleen indices of mice. Methotrexate markedly decreases white blood cells, thymic and splenic lymphocytes at dose ≥5 mg/kg. However, there is a significant difference between the treatment plus control group and the model group (p<0.01). The combination of grape seed proanthocyanidins and Siberian ginseng eleutherosides obviously diminishes the effects of Methotrexate exposure on indices of thymus and spleens in mice[2]. Methotrexate (MTX) (2 mg/kg; i.p.; once in a week for 5 weeks) is effective in Freund's complete adjuvant-induced arthritis. The combination of Methotrexate (1 mg/kg; i.p.; once in a week for 5 weeks) and Curcumin (30 mg/kg and 100 mg/kg, thrice a week for 5 weeks; i.p.) shows a significant anti-arthritic action and protection from hematological toxicity[3].
References

[1]. Balwant Singh, et al. Process for the preparation of high purity methotrexate and derivatives thereof. Patent US4374987A 87A

[2]. [2].Swierkot J, et al. Methotrexate in rheumatoid arthritis. Pharmacol Rep. 2006 Jul-Aug;58(4):473-92

[3]. Banji D, et al. Evaluation of the concomitant use of methotrexate and curcumin on Freund's complete adjuvant-induced arthritis and hematological indices in rats. Indian J Pharmacol. 2011;43(5):546-550.

 Chemical & Physical Properties

Density 2.6±0.1 g/cm3
Boiling Point 266.2±25.0 °C at 760 mmHg
Molecular Formula C3H3Br3O
Molecular Weight 294.767
Flash Point 115.1±9.7 °C
Exact Mass 291.773376
PSA 17.07000
LogP 3.25
Vapour Pressure 0.0±0.5 mmHg at 25°C
Index of Refraction 1.595

 Safety Information

HS Code 2914700090

 Synthetic Route

 Customs

HS Code 2914700090
Summary HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

 Synonyms

1,1,3-Tribromoacetone
1,1,3-tribromopropanone
1,1,3-Tribrom-aceton
1,1,3-tribromo-propan-2-one
1,3-Tribromoacetone
2-Propanone, 1,1,3-tribromo-
1,1,3-tribromo-2-propanone
2-Propanone,1,3-tribromo
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Chemsrc provides 1,1,3-Tribromoacetone(CAS#:3475-39-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of 1,1,3-Tribromoacetone are included as well.>> amp version: 1,1,3-Tribromoacetone

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